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melanoma

Tumor Endothelial Cell-Induced CD8(+) T-cell Exhaustion via GPNMB in Hepatocellular Carcinoma

[Cancer Science] Scientists investigated how tumor epithelial cells influenced tumor growth and immune responses of hepatocellular carcinoma focusing on CD8+ T-cell infiltration and exhaustion.

Targeting SOX10-Deficient Cells to Reduce the Dormant-Invasive Phenotype State in Melanoma

[Nature Communications] The authors identified the class of cellular inhibitor of apoptosis protein-1/2 inhibitors as inducing cell death selectively in SOX10-deficient cells.

Increased Expression of Viral Sensor MDA5 in Pancreatic Islets and in Hormone-Negative Endocrine Cells in Recent Onset Type 1 Diabetic Donors

[Frontiers in Immunology] The authors used multiplex immunofluorescence imaging analysis to characterize MDA5 expression and distribution in pancreatic tissues obtained from 22 organ donors.

Nobiletin Induces Ferroptosis in Human Skin Melanoma Cells Through the GSK3β-Mediated Keap1/Nrf2/HO-1 Signaling Pathway

[Frontiers in Genetics] The authors reported that nobiletin, a natural product isolated from citrus peel, exhibited antitumor activity by inducing ferroptosis in melanoma cells.

PLA2G6 Silencing Suppresses Melanoma Progression and Affects Ferroptosis Revealed by Quantitative Proteomics

[Frontiers in Oncology] Investigators revealed that PLA2G6 was up-regulated in cutaneous malignant melanoma tissues compared to nevus tissues, as well as increased in vitro in SK-MEL-28 and M14 melanoma cell lines compared to human melanocytes.

LINC01063 Functions as an Oncogene in Melanoma through Regulation of MiR-5194-Mediated SOX12 Expression

[Melanoma Research] LINC01063 knockdown impeded melanoma cell proliferation, migration, invasion, and epithelial-mesenchymal transition as well as melanoma tumor growth.

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