mesenchymal cells

[Artificial Organs] In vitro studies showed, wharton’s jelly-derived-MSCs that differentiated in the 3D culture have strong properties of insulin-producing cells such as islet-like cells.

[Communications Biology] Researchers showed that the number of p15INK4B + PDGFRα + senescent mesenchymal cells in adipose tissue increased transiently during early phases of wound healing in both non-diabetic mice and humans.

[Scientific Reports] The authors described a novel subset of renal perivascular MSCs that expressed Meflin, a glycosylphosphatidylinositol-anchored protein that was recently identified as a marker of fibroblasts essential for cardiac tissue repair.

[Molecular Oncology] Whether TGFβ promoted stemness and invasiveness simultaneously via epithelial-mesenchymal transition remained unclear. They established a breast cancer cell model expressing red fluorescent protein under the E-cadherin promoter.

[Stem Cell Reviews and Reports] Scientists summarize the biological effects and mechanisms of action of MSCs, elucidating recent clinical trials phases and findings, and highlighting therapeutic effects of MSCs in several representative diseases

[Cell Research] The authors demonstrated that Lepr+ MSCs surrounding intestinal crypts sensed diet change and provided a novel niche signal to maintain intestinal stem cell and progenitor cell proliferation.