Oncogenic KRAS-Expressing Organoids with Biliary Epithelial Stem Cell Properties Give Rise to Biliary Tract Cancer in Mice

Researchers isolated epithelial cell adhesion molecule-positive biliary epithelial cells from the mouse intrahepatic bile duct, gallbladder, and extrahepatic bile duct and established organoids derived from these cells.
[Cancer Science]
Kasuga, A., Semba, T., Sato, R., Nobusue, H., Sugihara, E., Takaishi, H., Kanai, T., Saya, H., & Arima, Y. (n.d.). Oncogenic KRAS–expressing organoids with biliary epithelial stem cell properties give rise to biliary tract cancer in mice. Cancer Science, n/a(n/a). https://doi.org/10.1111/cas.14703 Cite
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Generation of Human Induced Pluripotent Stem Cell-Derived Liver Buds with Chemically Defined and Animal Origin-Free Media

Scientists developed a defined, animal origin-free (CD-AOF) medium to generate all induced pluripotent stem cell-liver buds. Scientists developed a CD-AOF medium for hepatocytes, endothelial cells, and stage-matched mesenchymal stem cells i.e., septum transversum mesenchyme, in 2D cultures.
[Scientific Reports]
Sekine, K., Ogawa, S., Tsuzuki, S., Kobayashi, T., Ikeda, K., Nakanishi, N., Takeuchi, K., Kanai, E., Otake, Y., Okamoto, S., Kobayashi, T., Takebe, T., & Taniguchi, H. (2020). Generation of human induced pluripotent stem cell-derived liver buds with chemically defined and animal origin-free media. Scientific Reports, 10(1), 17937. https://doi.org/10.1038/s41598-020-73908-1 Cite
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Antioxidant and Biological Properties of Mesenchymal Cells Used for Therapy in Retinitis Pigmentosa

Scientists summarize the current neuroscientific evidence regarding the effectiveness of cell therapies in Retinitis pigmentosa, especially those based on MSCs, and they focus on their therapeutic action: limitation of both oxidative stress and apoptotic processes triggered by the disease and promotion of cell survival.
[Antioxidants]
Limoli, P. G., Vingolo, E. M., Limoli, C., & Nebbioso, M. (2020). Antioxidant and Biological Properties of Mesenchymal Cells Used for Therapy in Retinitis Pigmentosa. Antioxidants, 9(10), 983. https://doi.org/10.3390/antiox9100983 Cite
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ZFP423 Regulates Early Patterning and Multiciliogenesis in the Hindbrain Choroid Plexus

Zfp423, encoding a Kruppel-type zinc finger transcription factor essential for cerebellar development and mutated in rare cases of cerebellar vermis hypoplasia / Joubert syndrome and other ciliopathies, is expressed in the hindbrain roof plate, from which the IV ventricle choroid plexus arises, and, later, in MSCs giving rise to the stroma and leptomeninges.
[Development]
Casoni, F., Croci, L., Vincenti, F., Podini, P., Riba, M., Massimino, L., Cremona, O., & Consalez, G. G. (2020). ZFP423 regulates early patterning and multiciliogenesis in the hindbrain choroid plexus. Development. https://doi.org/10.1242/dev.190173 Cite
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Multilineage Murine Stem Cells Generate Complex Organoids to Model Distal Lung Development and Disease

The authors established a three‐dimensional murine bronchioalveolar lung organoid model that allows clonal expansion and self‐organization of FACS‐sorted bronchioalveolar stem cells upon co‐culture with lung‐resident mesenchymal cells.
[EMBO Journal]
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Pancreatic Cancer Cells Require the Transcription Factor MYRF to Maintain ER Homeostasis

Investigators found that pancreatic ductal adenocarcinomas overexpressed the myelin regulatory factor, an ER membrane-associated transcription factor released by self-cleavage.
[Developmental Cell]
Milan, M., Balestrieri, C., Alfarano, G., Polletti, S., Prosperini, E., Nicoli, P., Spaggiari, P., Zerbi, A., Cirulli, V., Diaferia, G. R., & Natoli, G. (2020). Pancreatic Cancer Cells Require the Transcription Factor MYRF to Maintain ER Homeostasis. Developmental Cell, 0(0). https://doi.org/10.1016/j.devcel.2020.09.011 Cite
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Differentiation of Cells Isolated from Afterbirth Tissues into Hepatocyte-Like Cells and Their Potential Clinical Application in Liver Regeneration

Scientists summarize the results of preclinical and clinical studies dealing with the introduction of epithelial and mesenchymal stem cells of the afterbirth origin to the liver failure therapy.
[Stem Cell Reviews and Reports]
Michalik, M., Gładyś, A., & Czekaj, P. (2020). Differentiation of Cells Isolated from Afterbirth Tissues into Hepatocyte-Like Cells and Their Potential Clinical Application in Liver Regeneration. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-020-10045-2 Cite
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Raman-Guided Subcellular Pharmaco-Metabolomics for Metastatic Melanoma Cells

Scientists utilized Raman spectro-microscopy for spatial mapping of metabolites within single cells, with the specific goal of identifying druggable metabolic susceptibilities from a series of patient-derived melanoma cell lines.
[Nature Communications]
Du, J., Su, Y., Qian, C., Yuan, D., Miao, K., Lee, D., Ng, A. H. C., Wijker, R. S., Ribas, A., Levine, R. D., Heath, J. R., & Wei, L. (2020). Raman-guided subcellular pharmaco-metabolomics for metastatic melanoma cells. Nature Communications, 11(1), 4830. https://doi.org/10.1038/s41467-020-18376-x Cite
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Lung Mesenchymal Cells Elicit Lipid Storage in Neutrophils That Fuel Breast Cancer Lung Metastasis

In breast cancer models, scientists found that neutrophils were induced to accumulate neutral lipids upon interaction with resident mesenchymal cells in the premetastatic lung.
[Nature Immunology]
Li, P., Lu, M., Shi, J., Gong, Z., Hua, L., Li, Q., Lim, B., Zhang, X. H.-F., Chen, X., Li, S., Shultz, L. D., & Ren, G. (2020). Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis. Nature Immunology, 1–12. https://doi.org/10.1038/s41590-020-0783-5 Cite
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ABCA1 Plays an Anti-Inflammatory Role by Affecting TLR4 at the Feto–Maternal Interface

Primary amniotic mesenchymal cells (AMCs), chorion cells and decidual cells were isolated from placental membranes of women with uncomplicated pregnancies at full-term using enzymatic digestion.
[Life Sciences]
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Administration of Cardiac Mesenchymal Cells Modulates Innate Immunity in the Acute Phase of Myocardial Infarction in Mice

Researchers evaluated the consequences of cardiac mesenchymal cell administration on post myocardial infarction immune responses in vivo and paracrine-mediated immune cell function in vitro.
[Scientific Reports]
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