Tag results:

mesenchymal cells

A Novel Hybrid Polymer of PCL/Fish Gelatin Nanofibrous Scaffold Improves Proliferation and Differentiation of Wharton’s Jelly-Derived Mesenchymal Cells into Islet-Like Cells

[Artificial Organs] In vitro studies showed, wharton’s jelly-derived-MSCs that differentiated in the 3D culture have strong properties of insulin-producing cells such as islet-like cells.

Altered Regulation of Mesenchymal Cell Senescence in Adipose Tissue Promotes Pathological Changes Associated with Diabetic Wound Healing

[Communications Biology] Researchers showed that the number of p15INK4B + PDGFRα + senescent mesenchymal cells in adipose tissue increased transiently during early phases of wound healing in both non-diabetic mice and humans.

A Novel Renal Perivascular Mesenchymal Cell Subset Gives Rise to Fibroblasts Distinct from Classic Myofibroblasts

[Scientific Reports] The authors described a novel subset of renal perivascular MSCs that expressed Meflin, a glycosylphosphatidylinositol-anchored protein that was recently identified as a marker of fibroblasts essential for cardiac tissue repair.

TGFβ Selects for Pro-stemness over Pro-invasive Phenotypes during Cancer Cell Epithelial–Mesenchymal Transition

[Molecular Oncology] Whether TGFβ promoted stemness and invasiveness simultaneously via epithelial-mesenchymal transition remained unclear. They established a breast cancer cell model expressing red fluorescent protein under the E-cadherin promoter.

A Brief Overview of Global Trends in MSC-Based Cell Therapy

[Stem Cell Reviews and Reports] Scientists summarize the biological effects and mechanisms of action of MSCs, elucidating recent clinical trials phases and findings, and highlighting therapeutic effects of MSCs in several representative diseases

Lepr+ Mesenchymal Cells Sense Diet to Modulate Intestinal Stem/Progenitor Cells via Leptin–Igf1 Axis

[Cell Research] The authors demonstrated that Lepr+ MSCs surrounding intestinal crypts sensed diet change and provided a novel niche signal to maintain intestinal stem cell and progenitor cell proliferation.