Seamless Genetic Recording of Transiently Activated Mesenchymal Gene Expression in Endothelial Cells during Cardiac Fibrosis

Genetic fate mapping results revealed that a subset of cardiac endothelial cells transiently expressed αSMA and Zeb1 during embryonic valve formation and transdifferentiated into mesenchymal cells through EndoMT.
[Circulation]
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Fibroblast Pyruvate Carboxylase Is Required for Collagen Production in the Tumour Microenvironment

Using cultured mesenchymal and cancer cells, as well as mouse allograft models, the authors provide evidence that extracellular lactate could be utilized by fibroblasts to maintain tricarboxylic acid cycle anaplerosis and non-essential amino acid biosynthesis through pyruvate carboxylase activity.
[Nature Metabolism]
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MicroRNA-200c/429 Mediated Regulation of Zeb1 Augments N-cadherin in Mouse Cardiac Mesenchymal Cells

Scientists investigated the expression of N-Cadherin, a trans-membrane protein that enhanced the cell adhesion and recently gained attention for differentiation and augmentation of stem cell function, in mouse cardiac MSCs.
[Cell Biology International]
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Macrophages Orchestrate the Expansion of a Proangiogenic Perivascular Niche during Cancer Progression

Scientists demonstrated that Lyve-1+ tumor-associated macrophages supported tumor growth and identified a pivotal role for these cells in maintaining a population of perivascular mesenchymal cells that expressed α-smooth muscle actin and phenotypically resembled pericytes.
[Science Advances]
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Sensitization of the UPR by Loss of PPP1R15A Promotes Fibrosis and Senescence in IPF

Researchers demonstrated the major role of PPP1R15A in the regulation of lung mesenchymal cells, and regulation of PPP1R15A may represent a novel therapeutic strategy in idiopathic pulmonary fibrosis.
[Scientific Reports]
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Human Stem Cell-Derived Thymic Epithelial Cells Enhance Human T Cell Development in a Xenogeneic Thymus

Scientists generated human thymic epithelial progenitors from human embryonic stem cells and to assess their thymopoietic function in vivo.
[Journal of Allergy and Clinical Immunology]
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Improved Differentiation of hESC-Derived Pancreatic Progenitors by Using Human Fetal Pancreatic Mesenchymal Cells in a Micro‐Scalable Three-Dimensional Co-Culture System

The impact of 3D co-culture of human fetal pancreatic-derived mesenchymal cells with human embryonic stem cell-derived pancreatic progenitors development towards endocrine and beta cells was assessed.
[Stem Cell Reviews and Reports]
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Nance-Horan Syndrome-Like 1 Protein Negatively Regulates Scar/WAVE-Arp2/3 Activity and Inhibits Lamellipodia Stability and Cell Migration

The authors identified Nance-Horan Syndrome-like 1 protein as a direct binding partner of the Scar/WAVE complex, which co-localized at protruding lamellipodia.
[Nature Communications]
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Intrahepatic Cholangiocyte Regeneration from an Fgf-Dependent Extrahepatic Progenitor Niche in a Zebrafish Model of Alagille Syndrome

Researchers showed that intrahepatic duct cells regenerated upon resumption of Jag/Notch signaling, from multipotent progenitors originating from an Fgf-dependent extrahepatic stem cell niche.
[Hepatology]
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Hemicentin-1 Is an Essential Extracellular Matrix Component of the Dermal–Epidermal and Myotendinous Junctions

Performing in situ hybridization and immunofluorescence analysis, researchers found that mouse Hmcn1 and Hmcn2 showed a complementary distribution throughout different tissues and developmental stages.
[Scientific Reports]
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Oncostatin M Regulates Hematopoietic Stem Cell (HSC) Niches in the Bone Marrow to Restrict HSC Mobilization

Researchers showed that pro-inflammatory oncostatin M (OSM) was an important regulator of HSC niches in the bone marrow (BM). OSM up-regulated E-selectin expression on BM endothelial cells indirectly increasing HSC proliferation.
[Leukemia]
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