ERK/MAPK Signaling Is Essential for Intestinal Development through Wnt Pathway Modulation

Scientists found that deletion of Erk1/2 in intestinal epithelial cells at embryonic stages resulted in an unexpected increase in cell proliferation and migration, expansion of intestinal stem cells and formation of polyp-like structures, leading to postnatal death.
[Development]
ERK/MAPK signaling is essential for intestinal development through Wnt pathway modulation | Development. (n.d.). Retrieved August 7, 2020, from https://dev.biologists.org/content/early/2020/07/30/dev.185678 Cite
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HDAC Inhibitors Tune miRNAs in Extracellular Vesicles of Dystrophic Muscle-Resident Mesenchymal Cells

Investigators showed that extracellular vesicles released by mesenchymal cells mediated microRNAtransfer to muscle stem cells.
[EMBO Reports]
Sandonà, M., Consalvi, S., Tucciarone, L., De Bardi, M., Scimeca, M., Angelini, D. F., Buffa, V., D’Amico, A., Bertini, E. S., Cazzaniga, S., Bettica, P., Bouché, M., Bongiovanni, A., Puri, P. L., & Saccone, V. (2020). HDAC inhibitors tune miRNAs in extracellular vesicles of dystrophic muscle-resident mesenchymal cells. EMBO Reports, n/a(n/a), e50863. https://doi.org/10.15252/embr.202050863 Cite
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Discrete Adaptive Responses to MEK Inhibitor in Subpopulations of Triple-Negative Breast Cancer

The authors defined the differential responses to trametinib in subpopulations of a clinically-relevant in vitro model of TNBC, and identified both adaptive and acquired elements that contribute to the emergence of drug resistance mediated by increased expression of CXCR7 and amplification of KRAS.
[Molecular Cancer Research]
Discrete Adaptive Responses to MEK Inhibitor in Subpopulations of Triple-Negative Breast Cancer | Molecular Cancer Research. (n.d.). Retrieved August 6, 2020, from https://mcr.aacrjournals.org/content/early/2020/08/04/1541-7786.MCR-19-1011 Cite
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The Mesenchymal Context in Inflammation, Immunity and Cancer

Investigators provide a concise overview of the contextual contribution of fibroblastic mesenchymal cells in physiology and disease and bring into focus emerging evidence for both their heterogeneity at the single-cell level and their tissue-specific, spatiotemporal functional diversity.
[Nature Immunology]
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Glycogen Synthase Kinase‐3β Promotes Radiation‐Induced Lung Fibrosis by Regulating β‐Catenin/lin28 Signaling Network to Determine Type II Alveolar Stem Cell Transdifferentiation State

Scientists explored the expressions of cell phenotype markers and differentiation regulators in isolated type II alveolar epithelial stem cells (AEC II) to analyze the correlation between GSK‐3β/TGF‐β1/β‐catenin signaling pathway, lin28/let‐7 balance, and AEC II phenotypes at different injury phases following irradiation.
[FASEB Journal]
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Targeting Disseminated Estrogen-Receptor-Positive Breast Cancer Cells in Bone Marrow

Investigators utilized a 3D co-culture model incorporating estrogen receptor-positive breast cancer cells and bone marrow mesenchymal stem cells to represent disseminated tumors cells in a bone marrow niche.
[Oncogene]
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Intravenous Infusion of Umbilical Cord Mesenchymal Stem Cells Maintains and Partially Improves Visual Function in Patients with Advanced Retinitis Pigmentosa

Investigators conducted a Phase I/II clinical trial aiming to evaluate the safety and efficacy of intravenous administration of umbilical cord MSCs in advanced retinitis pigmentosa patients.
[Stem Cells and Development]
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Prophylactic Therapy with Human Amniotic Fluid Stem Cells Improved Survival in a Rat Model of Lipopolysaccharide-Induced Neonatal Sepsis through Immunomodulation via Aggregates with Peritoneal Macrophages

Amniotic fluid stem cells were isolated as CD117-positive cells from human amniotic fluid. Three-day-old rat pups were intraperitoneally treated with lipopolysaccharide to mimic neonatal sepsis.
[Stem Cell Research & Therapy]
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Regeneration of the Rotator Cuff Tendon-to-Bone Interface Using Umbilical Cord-Derived Mesenchymal Stem Cells and Gradient Extracellular Matrix Scaffolds from Adipose Tissue in a Rat Model

Researchers investigated the efficacy of a biomimetic hydroxyapatite-gradient scaffold isolated from adipose tissue with umbilical cord derived MSCs on the regeneration of the structure of the tendone-to-bone interface by analyzing the histological and biomechanical changes in a rat repair model.
[Acta Biomaterialia]
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hUC-MSCs Ameliorated CUMS-Induced Depression by Modulating Complement C3 Signaling-Mediated Microglial Polarization during Astrocyte-Microglia Crosstalk

Human umbilical cord (hUC)-MSCs were administered into chronic unpredictable mild stress model mice through the tail vein once a week for four weeks. After the administration of hUC-MSCs, the depression-like and anxiety-like phenotypes, neuronal histopathology, synaptic-related protein expression and inflammatory index of the mice were assessed.
[Brain Research Bulletin]
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Insights into the Hematopoietic Regulatory Activities of Osteoblast by Secretomics

The authors characterized the hematopoietic supporting activity of mesenchymal stromal cells‐derived osteoblast (M‐OST) conditioned media by comparing the secretome of M‐OST to that of their precursor.
[Proteomics]
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Control the Fate of Human Umbilical Cord Mesenchymal Stem Cells with Dual-Enzymatically Cross-Linked Gelatin Hydrogels for Potential Applications in Nerve Regeneration

Scientists proposed a new dual‐enzymatically cross‐linked and injectable gelatin hydrogel for regulating survival, proliferation and differentiation of human umbilical cord mesenchymal stem cells in three‐dimensional matrix.
[Journal of Tissue Engineering and Regenerative Medicine]
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