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mesenchymal cells

Dichotomy in Hypoxia-Induced Mitochondrial Fission in Placental Mesenchymal Cells during Development and Preeclampsia: Consequences for Trophoblast Mitochondrial Homeostasis

[Cell Death & Disease] The authors investigated the impact of oxygen on mitochondrial dynamics in placental MSCs that were vital for proper placental development.

Design, Synthesis, and Biological Evaluation of the First Inhibitors of Oncogenic CHD1L

[Journal of Medicinal Chemistry] Researchers described the optimization of the first lead chromodomain helicase DNA-binding protein 1 like inhibitors through drug design and medicinal chemistry.

Epithelial LIF Signaling Limits Apoptosis and Lung Injury during Bacterial Pneumonia

[American Journal of Physiology-Lung Cellular and Molecular Physiology] The authors demonstrated that antibody-induced leukemia inhibitory factor (LIF) blockade remodeled the lung epithelial transcriptome in association with increased apoptosis.

Mesenchymal-Epithelial Crosstalk Shapes Intestinal Regionalisation via Wnt and Shh Signalling

[Nature Communications] Scientists identified a mesenchymal-epithelial crosstalk that shapes the developing small intestine during late morphogenesis.

The Osteoprotective Role of USP26 in Coordinating Bone Formation and Resorption

[Cell Death & Differentiation] USP26 stabilized β-catenin to promote the osteogenic activity of MSCs and impaired the osteoclastic differentiation of bone myelomonocytes by stabilizing inhibitors of NF-κBα.

Colon Stroma Mediates an Inflammation-Driven Fibroblastic Response Controlling Matrix Remodeling and Healing

[PLoS Biology] Researchers performed single-cell RNA-sequencing of colon-derived stromal cells and identified distinct classes of fibroblasts with gene signatures that were differentially regulated by chronic inflammation, including IL-11–producing inflammatory fibroblasts.

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