mesenchymal cells

[Nature Communications] Researchers indicated that KLF4 played opposing roles in platelet-derived growth factor receptor-β+ cells and α-smooth muscle actin+ cells and highlighted the importance of further studies of interactions between distinct mesenchymal cell types.

[Nature Communications] Single-cell RNA-sequencing analysis identified Fap+ cells and Fsp1+ cells as the major contributors of Col1 in the bone. Scientists generated transgenic mouse models to genetically delete Col1 in various cell lineages.

[American Journal of Physiology-Lung Cellular and Molecular Physiology] To address limitations in cell culture and in vivo mechanotransductive models, scientists developed two mouse lung organoid mechanotransductive models using postnatal day five mouse lung CD326-positive cells and fibroblasts subjected to increased, decreased, and cyclic strain.

[Developmental Cell] Researchers employed tamoxifen-inducible dual recombinase lineage tracing systems combined with live imaging and 5-cell RNA sequencing to track cancer cells undergoing partial or full epithelial-mesenchymal transition (EMT) in the MMTV-PyMT mouse model of metastatic breast cancer.

[International Journal of Oral Science] By compounding Pax2-Cre and R26R-mTmG mice, the authors found a specific expression pattern of Pax2+ cells that marked branchial arch (BA1)'s mesenchymal cells and the BA1-derivatives.

[Cell Death & Disease] Scientists identified transcriptional programs of initiating and activated hepatic stellate cells by RNA sequencing, using in vitro and in vivo mouse models of fibrosis.