mesenchymal cells

[Nature Genetics] Investigators presented a single-cell and spatially resolved transcriptomics analysis of human breast cancers. They developed a single-cell method of intrinsic subtype classification to reveal recurrent neoplastic cell heterogeneity.

[Cell Reports] Researchers applied mass cytometry and uncover decidual-like natural killer cell subpopulations in newly diagnosed high-grade serous carcinoma samples that correlated with both tumor and transitioning epithelial-mesenchymal cell abundance.

[Life Sciences] One therapeutic approach showing a ray of hope to combat COVID-19 infection is MSC therapy. Mesenchymal cells have immunomodulatory, anti-inflammatory as well as regenerative properties and various preliminary studies have shown that MSCs can reverse the lung damage and overcome the cytokine storm incited by COVID-19 infection.

[Journal of Clinical Investigation] Scientists mice with endothelial-specific overexpression of DEL-1 were protected from arthritis relative to WT controls, while arthritis was exacerbated in DEL-1-deficient mice.

[Nature Biomedical Engineering] Scientists reported a protocol that leveraged PRRX1–tdTomato reporter human PSCs for the selective induction of expandable and ontogenetically defined PRRX1+ limb-bud-like mesenchymal cells under defined xeno-free conditions.

[Seminars in Cell & Developmental Biology] The authors review the emerging contribution of fibro-adipogenic progenitors to skeletal muscle responses to motor neuron injuries and to systemic physiological or pathological metabolic perturbations.