Researchers demonstrated that the RNAs related to cell proliferation and astrocyte differentiation were upregulated in human mesenchymal stem cells when co-cultured with exosomes obtained from the culture medium of human glioma cells.
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Glioma-derived exosomes drive the differentiation of neural stem cells to astrocytes. (n.d.). Retrieved July 13, 2020, from https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234614 Cite
Investigators report that the cardioprotective properties of intravenously injected MSCs in a mouse model of pressure-overload heart failure largely depend on circulating adiponectin, an adipocyte-secreted factor.
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Adiponectin Stimulates Exosome Release to Enhance Mesenchymal Stem-Cell-Driven Therapy of Heart Failure in Mice: Molecular Therapy. (n.d.). Retrieved July 14, 2020, from https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(20)30316-6#%20 Cite
The authors report that a remarkable shift in epithelial cell phenotypes occured in the peripheral lung in pulmonary fibrosis and identified several previously unrecognized epithelial cell phenotypes.
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Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis | Science Advances. (n.d.). Retrieved July 14, 2020, from https://advances.sciencemag.org/content/6/28/eaba1972 Cite
Effects of umbilical cord-mesenchymal stem cell-conditioned medium on insulin resistance were evaluated using glucose uptake, glucose transporter type 4 translocation, the insulin-signaling pathway, and mitochondrial contents and functions in C2C12 cell.
[Diabetes & Metabolism Journal]
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With an urgent need for the development of potential strategies, two recent studies from China using MSCs to treat COVID-19 pneumonia have shed some light on a potential cure for the COVID-19 infected patients.
[Stem Cell Reviews and Reports]
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Researchers developed a combined nano-cell therapy by using dendrimers complexed with plasmids targeting CCL20 and its sole receptor CCR6 to reduce inflammation followed by human mesenchymal stem cell transplantation.
[Nanomedicine-Nanotechnology Biology and Medicine]
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Scientists aimed to determine whether human bone marrow mesenchymal stem cells can differentiate into biliary epithelial cells in vitro and in vivo and to clarify the role of delta-like ligand 4 (DLL4) in restoring damaged liver by enhancing cholangiocyte differentiation.
[Stem Cell Research]
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Investigators demonstrated 89Zr-oxine labeling and PET-CT imaging as a potential clinical solution for non-invasively tracking MSCTRAIL biodistribution
[Stem Cell Research & Therapy]
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Scientists evaluated the antimicrobial activity and therapeutic effect of local treatment with antibiotic-loaded adipose-derived stem cells plus an antibiotic in a rat implant-associated infection model.
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Yoshitani, J., Kabata, T., Arakawa, H., Kato, Y., Nojima, T., Hayashi, K., Tokoro, M., Sugimoto, N., Kajino, Y., Inoue, D., Ueoka, K., Yamamuro, Y., & Tsuchiya, H. (2020). Combinational therapy with antibiotics and antibiotic-loaded adipose-derived stem cells reduce abscess formation in implant-related infection in rats. Scientific Reports, 10(1), 11182. https://doi.org/10.1038/s41598-020-68184-y Cite
Researchers utilised cell sorting and immunohistochemistry to identify a phenotypically-distinct, osteogenically-committed bone marrow stromal cell subset in human osteoarthritis trabecular bone.
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Ilas, D. C., Baboolal, T. G., Churchman, S. M., Jones, W. G., Giannoudis, P. V., Bühring, H.-J., McGonagle, D., & Jones, E. (2020). The osteogenic commitment of CD271+CD56+ bone marrow stromal cells (BMSCs) in osteoarthritic femoral head bone. Scientific Reports, 10(1), 11145. https://doi.org/10.1038/s41598-020-67998-0 Cite
Investigators observed increased migration and reduced proliferation and differentiation when keratinocytes were co-cultured in media conditioned by human amniotic epithelial cell and human amniotic mesenchymal stem cells.