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mesenchymal stem cells

Intravenous Administration of Human Mesenchymal Stem Cells Derived from Adipose Tissue and Umbilical Cord Improves Neuropathic Pain via Suppression of Neuronal Damage and Anti-Inflammatory...

[PLoS One] The authors investigated the effects of human adipose tissue- and umbilical cord-MSCs on neuropathic pain and its mechanisms using rat models of partial sciatic nerve ligation

MiR-155 Inhibits TP53INP1 Expression Leading to Enhanced Glycolysis of Psoriatic Mesenchymal Stem Cells

[Journal of Dermatological Science] Researchers investigated whether miR-155 regulated glycolysis of psoriasis and the underlying mechanisms. Human dermal-derived MSCs were treated with miR-155 mimic or inhibitor, followed by assessments of cells proliferation, metabolism and inflammatory response.

3D Print Platelet-Rich Plasma Loaded Scaffold with Sustained Cytokine Release for Bone Defect Repair

[Tissue Engineering Part A] Investigators demonstrated that their composite scaffold with platelet-rich plasma/gelatin microspheres led to greater positive effects in promoting large bone defect repair.

Stem Cell-Based Tissue Engineering for the Treatment of Burn Wounds: A Systematic Review of Preclinical Studies

[Stem Cell Reviews and Reports] Current treatment methods for burn wounds are far from ideal, driving the need for tissue engineered solutions. Among various approaches, stem cell-based strategies are promising candidates for improving the treatment of burn wounds.

Multiwell Combinatorial Hydrogel Array for High-Throughput Analysis of Cell-ECM Interactions

[Biophysical Journal] Researchers developed a platform that utilized orthogonal photopatterning of stiffness and adhesivity gradients to fabricate individually accessible wells with discrete ECM conditions.

PLA/Hydroxyapatite Scaffolds Exhibit In Vitro Immunological Inertness and Promote Robust Osteogenic Differentiation of Human Mesenchymal Stem Cells without Osteogenic Stimuli

[Scientific Reports] Evaluations using human MSCs showed that pure polylactic acid (PLA) scaffolds exerted an osteoconductive effect, whereas PLA/hydroxyapatite scaffolds efficiently induced osteogenic differentiation of MSCs even in the absence of any classical osteogenic stimuli.

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