Glioma-Derived Exosomes Drive the Differentiation of Neural Stem Cells to Astrocytes

Researchers demonstrated that the RNAs related to cell proliferation and astrocyte differentiation were upregulated in human mesenchymal stem cells when co-cultured with exosomes obtained from the culture medium of human glioma cells.
[PLoS One]
Glioma-derived exosomes drive the differentiation of neural stem cells to astrocytes. (n.d.). Retrieved July 13, 2020, from https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234614 Cite
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Adiponectin Stimulates Exosome Release to Enhance Mesenchymal Stem-Cell-Driven Therapy of Heart Failure in Mice

Investigators report that the cardioprotective properties of intravenously injected MSCs in a mouse model of pressure-overload heart failure largely depend on circulating adiponectin, an adipocyte-secreted factor.
[Molecular Therapy]
Adiponectin Stimulates Exosome Release to Enhance Mesenchymal Stem-Cell-Driven Therapy of Heart Failure in Mice: Molecular Therapy. (n.d.). Retrieved July 14, 2020, from https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(20)30316-6#%20 Cite
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Single-Cell RNA Sequencing Reveals Profibrotic Roles of Distinct Epithelial and Mesenchymal Lineages in Pulmonary Fibrosis

The authors report that a remarkable shift in epithelial cell phenotypes occured in the peripheral lung in pulmonary fibrosis and identified several previously unrecognized epithelial cell phenotypes.
[Science Advances]
Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis | Science Advances. (n.d.). Retrieved July 14, 2020, from https://advances.sciencemag.org/content/6/28/eaba1972 Cite
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Umbilical Cord-Mesenchymal Stem Cell-Conditioned Medium Improves Insulin Resistance in C2C12 Cell

Effects of umbilical cord-mesenchymal stem cell-conditioned medium on insulin resistance were evaluated using glucose uptake, glucose transporter type 4 translocation, the insulin-signaling pathway, and mitochondrial contents and functions in C2C12 cell.
[Diabetes & Metabolism Journal]
Kim, K.-S., Choi, Y. K., Kim, M. J., Hwang, J. W., Min, K., Jung, S. Y., Kim, S.-K., Choi, Y.-S., & Cho, Y.-W. (2020). Umbilical Cord-Mesenchymal Stem Cell-Conditioned Medium Improves Insulin Resistance in C2C12 Cell. Diabetes & Metabolism Journal, 44. https://doi.org/10.4093/dmj.2019.0191 Cite
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Mesenchymal Stem Cell Derived Exosomes: a Nano Platform for Therapeutics and Drug Delivery in Combating COVID-19

With an urgent need for the development of potential strategies, two recent studies from China using MSCs to treat COVID-19 pneumonia have shed some light on a potential cure for the COVID-19 infected patients.
[Stem Cell Reviews and Reports]
Pinky, Gupta, S., Krishnakumar, V., Sharma, Y., Dinda, A. K., & Mohanty, S. (2020). Mesenchymal Stem Cell Derived Exosomes: a Nano Platform for Therapeutics and Drug Delivery in Combating COVID-19. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-020-10002-z Cite
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Treatment with shCCL20-CCR6 Nanodendriplexes and Human Mesenchymal Stem Cell Therapy Improves Pathology in Mice with Repeated Traumatic Brain Injury

Researchers developed a combined nano-cell therapy by using dendrimers complexed with plasmids targeting CCL20 and its sole receptor CCR6 to reduce inflammation followed by human mesenchymal stem cell transplantation.
[Nanomedicine-Nanotechnology Biology and Medicine]
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DLL4 Restores Damaged Liver by Enhancing hBMSC Differentiation into Cholangiocytes

Scientists aimed to determine whether human bone marrow mesenchymal stem cells can differentiate into biliary epithelial cells in vitro and in vivo and to clarify the role of delta-like ligand 4 (DLL4) in restoring damaged liver by enhancing cholangiocyte differentiation.
[Stem Cell Research]
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Lung Delivery of MSCs Expressing Anti-Cancer Protein TRAIL Visualized with 89Zr-Oxine PET-CT

Investigators demonstrated 89Zr-oxine labeling and PET-CT imaging as a potential clinical solution for non-invasively tracking MSCTRAIL biodistribution
[Stem Cell Research & Therapy]
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Combinational Therapy with Antibiotics and Antibiotic-Loaded Adipose-Derived Stem Cells Reduce Abscess Formation in Implant-Related Infection in Rats

Scientists evaluated the antimicrobial activity and therapeutic effect of local treatment with antibiotic-loaded adipose-derived stem cells plus an antibiotic in a rat implant-associated infection model.
[Scientific Reports]
Yoshitani, J., Kabata, T., Arakawa, H., Kato, Y., Nojima, T., Hayashi, K., Tokoro, M., Sugimoto, N., Kajino, Y., Inoue, D., Ueoka, K., Yamamuro, Y., & Tsuchiya, H. (2020). Combinational therapy with antibiotics and antibiotic-loaded adipose-derived stem cells reduce abscess formation in implant-related infection in rats. Scientific Reports, 10(1), 11182. https://doi.org/10.1038/s41598-020-68184-y Cite
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The Osteogenic Commitment of CD271+CD56+ Bone Marrow Stromal Cells (BMSCs) in Osteoarthritic Femoral Head Bone

Researchers utilised cell sorting and immunohistochemistry to identify a phenotypically-distinct, osteogenically-committed bone marrow stromal cell subset in human osteoarthritis trabecular bone.
[Scientific Reports]
Ilas, D. C., Baboolal, T. G., Churchman, S. M., Jones, W. G., Giannoudis, P. V., Bühring, H.-J., McGonagle, D., & Jones, E. (2020). The osteogenic commitment of CD271+CD56+ bone marrow stromal cells (BMSCs) in osteoarthritic femoral head bone. Scientific Reports, 10(1), 11145. https://doi.org/10.1038/s41598-020-67998-0 Cite
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LOXL2 from Human Amniotic Mesenchymal Stem Cells Accelerates Wound Epithelialization by Promoting Differentiation and Migration of Keratinocytes

Investigators observed increased migration and reduced proliferation and differentiation when keratinocytes were co-cultured in media conditioned by human amniotic epithelial cell and human amniotic mesenchymal stem cells.
[Aging-Us]
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