mesenchymal stem cells

[Stem Cell Reviews and Reports] The authors unveiled the role of MSCs in regulating the brain sirtuin-1 (SIRT-1) levels following stroke and the involvement of SIRT-1 in regulating inflammasome signaling to reduce cellular apoptosis towards rendering neuroprotection.

[Platelets] The authors discuss the mechanisms of platelet mitochondrial translocation and metabolic reprogramming of MSCs, suggesting that platelets or platelet-containing preparations such as platelet-rich plasma may provide a practical guide for tissue injury treatment.

[Scientific Reports] Scientists demonstrated that the combination of extrinsic photobiomodulation and collagen-covered microislands could be used to induce differentiation of Wharton’s jelly MSCs with the differentiation direction dictated by the specific island topography without use of chemical factors.

[Molecular Biology Reports] Scientists optimized and functionally linked magnetic activated cell sorting technology as well as multiplex droplet digital PCR to their ESC screening process to achieve a greater than 60% assurance that ESC clones were correctly targeted.

[Bone & Joint Journal] Synovium-derived MSCs (SMSCs) were isolated from synovium specimens of patients undergoing temporomandibular joint surgery. Chondrogenic differentiation potential of SMSCs was evaluated in vitro in the control, IL-1β stimulation, and IL-1β stimulation with histone deacetylase inhibitors groups.

[Molecular Therapy Oncolytics] Investigators loaded umbilical cord-derived MSCs with oncolytic adenoviruses expressing decorin or without foreign genes to treat breast cancer lung metastasis.