Celltex Therapeutics Receives Another FDA Approval: Phase II Clinical Trial Using Mesenchymal Stem Cells (MSCs) as a Prophylactic Against COVID-19

Celltex announced that it has received approval from the FDA to proceed with the Company’s Investigational New Drug application to investigate the Prophylactic Efficacy of Autologous Adipose Tissue-Derived Mesenchymal Stem Cells against Coronavirus Disease 2019.
[Celltex]
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miR-146b-5p Suppresses the Malignancy of GSC/MSC Fusion Cells by Targeting SMARCA5

miR-146b-5p was downregulated in glioma stem-like cell/mesenchymal stem cell fusion cells, and its overexpression suppressed proliferation, migration and invasion by the fusion cells.
[Aging]
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Etoposide-Mediated Interleukin-8 Secretion from Bone Marrow Stromal Cells Induces Hematopoietic Stem Cell Mobilization

Investigators assessed the mechanism of hematopoietic stem cell mobilization using etoposide with granulocyte-colony stimulating factor (G-CSF), and determined how this mechanism differs from that induced by cyclophosphamide with G-CSF or G-CSF alone.
[BMC Cancer]
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Allogeneic Adipose-Derived Stem Cells Promote Ischemic Muscle Repair by Inducing M2 Macrophage Polarization via the HIF -1α/IL -10 Pathway

Scientists found that the ability of RAW264.7 cells to migrate was impaired in hypoxia, whereas coculturing with adipose‐derived mesenchymal stem cells could enhance the migration capacity.
[Stem Cells]
Liu, J., Qiu, P., Qin, J., Wu, X., Wang, X., Yang, X., Li, B., Zhang, W., Ye, K., Peng, Z., & Lu, X. (n.d.). Allogeneic adipose-derived stem cells promote ischemic muscle repair by inducing M2 macrophage polarization via the HIF-1α/IL-10 pathway. STEM CELLS, n/a(n/a). https://doi.org/10.1002/stem.3250 Cite
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Alternative Splicing in Mesenchymal Stem Cell Differentiation

The authors highlight the key alternative splicing (AS) events that modulate MSC differentiation to major osteocytes, chondrocytes, and adipocytes, and discuss the regulatory mechanisms by which AS is regulated.
[Stem Cells]
Park, J. W., Fu, S., Huang, B., & Xu, R.-H. (n.d.). Alternative splicing in mesenchymal stem cell differentiation. STEM CELLS, n/a(n/a). https://doi.org/10.1002/stem.3248 Cite
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Burns in the Elderly: Potential Role of Stem Cells

The authors review the potential use of stem cells in elderly burn wounds, as well as the mechanisms by which mesenchymal stem cell- based therapies may impact burn wound healing in the elderly.
[International Journal of Molecular Sciences]
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Functional Changes in Decidual Mesenchymal Stem/Stromal Cells are Associated with Spontaneous Onset of Labour

Decidual MSCs displayed stem cell-like properties and were of maternal origin. Important cell properties and lipid profiles were assessed and compared between spontaneous onset of labor- and not in labor-decidual MSCs.
[Molecular Human Reproduction]
Wijaya, J. C., Khanabdali, R., Georgiou, H. M., Kokkinos, M. I., James, P. F., Brennecke, S. P., & Kalionis, B. (n.d.). Functional Changes in Decidual Mesenchymal Stem/Stromal Cells are Associated with Spontaneous Onset of Labour. Molecular Human Reproduction. https://doi.org/10.1093/molehr/gaaa045 Cite
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Bone Marrow-Derived Mesenchymal Stem Cells Improve Cognitive Impairment in an Alzheimer’s Disease Model by Increasing the Expression of MicroRNA-146a in Hippocampus

Investigators showed that intracerebroventricularly injected bone marrow mesenchymal stem cells improved cognitive impairment in Alzheimer’s disease model mice by ameliorating astrocytic inflammation as well as synaptogenesis.
[Scientific Reports]
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Peripheral Blood As a Source of Stem Cells for Regenerative Medicine: Emphasis towards Corneal Epithelial Reconstruction – An In Vitro Study

Rabbit peripheral blood-derived mononuclear cells were isolated using density gradient centrifugation and was evaluated for mesenchymal cell properties including stemness.
[Journal of Tissue Engineering and Regenerative Medicine]
Venugopal, B., Mohan, S., Kumary, T. V., & Anil Kumar, P. R. (2020). Peripheral Blood As a Source of Stem Cells for Regenerative Medicine: Emphasis Towards Corneal Epithelial Reconstruction—An In Vitro Study. Tissue Engineering and Regenerative Medicine. https://doi.org/10.1007/s13770-020-00273-5 Cite
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miR-132-3p Priming Enhances the Effects of Mesenchymal Stromal Cell-Derived Exosomes on Ameliorating Brain Ischemic Injury

Mesenchymal stromal cell-derived exosomes could deliver their carried miR-132-3p into target ECs, which functionally downregulated the target protein RASA1, while upregulated the expression of Ras and the downstream PI3K phosphorylation.
[Stem Cell Research & Therapy]
Pan, Q., Kuang, X., Cai, S., Wang, X., Du, D., Wang, J., Wang, Y., Chen, Y., Bihl, J., Chen, Y., Zhao, B., & Ma, X. (2020). miR-132-3p priming enhances the effects of mesenchymal stromal cell-derived exosomes on ameliorating brain ischemic injury. Stem Cell Research & Therapy, 11(1), 260. https://doi.org/10.1186/s13287-020-01761-0 Cite
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Co‑Transplantation of Tonsil‑Derived Mesenchymal Stromal Cells in Bone Marrow Transplantation Promotes Thymus Regeneration and T Cell Diversity following Cytotoxic Conditioning

Researchers found that the co‑transplantation of tonsil‑derived mesenchymal stromal cells (T‑MSCs) with bone marrow‑derived cells (BMCs) accelerated the recovery of involuted thymuses in mice following partial pre‑bone marrow transplantation conditioning with busulfan‑cyclophosphamide treatment, possibly by inducing FMS‑like tyrosine kinase 3 ligand and fibroblast growth factor 7 production in T‑MSCs.
[International Journal of Molecular Medicine]
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