mesenchymal stem cells

[Cellular and Molecular Life Sciences] Scientists showed that the signaling protein WNT3A counteracted the induction of paracrine senescence in cultured human adult MSCs.

[International Journal of Oral Science] Investigators assessed the cell fate of PRX1+ cells during molar development and periodontal ligament (PDL) formation in mice, and performed single-cell RNA sequencing analysis to study the distribution of PRX1+ cells in PDL cells.

[Cell Death Discovery] Researchers investigated the physiological mechanisms by which extracellular vesicle-encapsulated miR-181a–2–3p derived from MSCs might mediate oxidative stress in Parkinson’s disease

[Journal of Biomedical Materials Research Part A] The effect of 3D printed polycaprolactone/polypyrrole conductive scaffolds on differentiation of human olfactory ecto-MSCs into functional Schwann cell-like phenotypes was investigated.

[Cancer Research] Scientists generated models of sarcomas bearing kinase fusions and assessed their response to molecularly targeted therapy. Immortalized, untransformed human MSCs, a putative cell-of-origin of sarcomas, were modified using CRISPR-Cas9 to harbor a RET chromosomal translocation.

[European Journal of Pharmaceutics and Biopharmaceutics] Researchers demonstrated the capacity of licensing hydrogel-encapsulated human MSCs to limit the in vivo progression of inflammatory bowel diseases.