mesenchymal stem cells

[Stem Cell Research & Therapy] The authors investigated the effect of hematopoietic cells on MSCs using various methods, including flow cytometry, adipogenic and osteogenic differentiation analysis, quantitative PCR, western bloting, and microCT analysis.

[Stem Cell Research & Therapy] Scientists overview recent in vivo reports rendering the therapeutic benefits of the MSCs-based therapies to ease skin wound healing, and so improving quality of life among patients suffering from such conditions.

[Cartesian Therapeutics] Cartesian Therapeutics announced that it has dosed the first patient in a Phase I/IIa multicenter clinical study evaluating Descartes-25, engineered to deliver a combination of synergistically active anti-myeloma therapies directly to tumor microenvironment, in patients with multiple myeloma.

[Medical Oncology] Researchers employed a co-culture system to clarify the effects of human amniotic mesenchymal stromal cells secretome through tyrosine phosphorylation of c-Src, SGK223, AKT activity, and JAK1/Stat3 signaling in Panc1 pancreatic cancer cells.

[Xilio Therapeutics, Inc.] Xilio Therapeutics, Inc. announced that the first patient has been dosed in the company’s Phase I/II clinical trial evaluating XTX202 for the treatment of solid tumors. XTX202 is a modified form of IL-2 that is designed to localize activity in the tumor microenvironment.

[Molecular Immunology] Scientists investigated the therapeutic effect of miR-223 in exosomes secreted by bone marrow MSCs on immune response in the progression of rheumatoid arthritis.