Combinational Therapy with Antibiotics and Antibiotic-Loaded Adipose-Derived Stem Cells Reduce Abscess Formation in Implant-Related Infection in Rats

Scientists evaluated the antimicrobial activity and therapeutic effect of local treatment with antibiotic-loaded adipose-derived stem cells plus an antibiotic in a rat implant-associated infection model.
[Scientific Reports]
Yoshitani, J., Kabata, T., Arakawa, H., Kato, Y., Nojima, T., Hayashi, K., Tokoro, M., Sugimoto, N., Kajino, Y., Inoue, D., Ueoka, K., Yamamuro, Y., & Tsuchiya, H. (2020). Combinational therapy with antibiotics and antibiotic-loaded adipose-derived stem cells reduce abscess formation in implant-related infection in rats. Scientific Reports, 10(1), 11182. https://doi.org/10.1038/s41598-020-68184-y Cite
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The Osteogenic Commitment of CD271+CD56+ Bone Marrow Stromal Cells (BMSCs) in Osteoarthritic Femoral Head Bone

Researchers utilised cell sorting and immunohistochemistry to identify a phenotypically-distinct, osteogenically-committed bone marrow stromal cell subset in human osteoarthritis trabecular bone.
[Scientific Reports]
Ilas, D. C., Baboolal, T. G., Churchman, S. M., Jones, W. G., Giannoudis, P. V., Bühring, H.-J., McGonagle, D., & Jones, E. (2020). The osteogenic commitment of CD271+CD56+ bone marrow stromal cells (BMSCs) in osteoarthritic femoral head bone. Scientific Reports, 10(1), 11145. https://doi.org/10.1038/s41598-020-67998-0 Cite
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LOXL2 from Human Amniotic Mesenchymal Stem Cells Accelerates Wound Epithelialization by Promoting Differentiation and Migration of Keratinocytes

Investigators observed increased migration and reduced proliferation and differentiation when keratinocytes were co-cultured in media conditioned by human amniotic epithelial cell and human amniotic mesenchymal stem cells.
[Aging-Us]
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Allogeneic Adipose-Derived Stem Cells Promote Ischemic Muscle Repair by Inducing M2 Macrophage Polarization via the HIF -1α/IL -10 Pathway

Scientists found that the ability of RAW264.7 cells to migrate was impaired in hypoxia, whereas coculturing with adipose‐derived mesenchymal stem cells could enhance the migration capacity.
[Stem Cells]
Liu, J., Qiu, P., Qin, J., Wu, X., Wang, X., Yang, X., Li, B., Zhang, W., Ye, K., Peng, Z., & Lu, X. (n.d.). Allogeneic adipose-derived stem cells promote ischemic muscle repair by inducing M2 macrophage polarization via the HIF-1α/IL-10 pathway. STEM CELLS, n/a(n/a). https://doi.org/10.1002/stem.3250 Cite
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Activating PIK3CA Mutation Promotes Osteogenesis of Bone Marrow Mesenchymal Stem Cells in Macrodactyly

Activating PIK3CA mutations and activation of PI3K/AKT/mTOR pathway were detected in all macrodactyly-derived bone marrow mesenchymal stem cells (MAC-BMSCs). MAC-BMSCs had enhanced osteogenesis potential compared with polydactyly-derived-BMSCs.
[Cell Death & Disease]
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Bone Marrow Stromal Cells-Derived microRNA-181-Containing Extracellular Vesicles Inhibit Ovarian Cancer Cell Chemoresistance by Downregulating MEST via the Wnt/β-Catenin Signaling Pathway

Extracellular vesicles (EVs) were isolated from bone marrow stromal cells (BMSCs) and co-cultured with ovarian cancer cells to further investigate the effects of overexpressed miR-181 delivered by BMSCs-derived EVs on ovarian cancer cell resistance to cisplatin.
[Cancer Gene Therapy]
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Celltex Therapeutics Receives Another FDA Approval: Phase II Clinical Trial Using Mesenchymal Stem Cells (MSCs) as a Prophylactic Against COVID-19

Celltex announced that it has received approval from the FDA to proceed with the Company’s Investigational New Drug application to investigate the Prophylactic Efficacy of Autologous Adipose Tissue-Derived Mesenchymal Stem Cells against Coronavirus Disease 2019.
[Celltex]
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miR-146b-5p Suppresses the Malignancy of GSC/MSC Fusion Cells by Targeting SMARCA5

miR-146b-5p was downregulated in glioma stem-like cell/mesenchymal stem cell fusion cells, and its overexpression suppressed proliferation, migration and invasion by the fusion cells.
[Aging]
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Etoposide-Mediated Interleukin-8 Secretion from Bone Marrow Stromal Cells Induces Hematopoietic Stem Cell Mobilization

Investigators assessed the mechanism of hematopoietic stem cell mobilization using etoposide with granulocyte-colony stimulating factor (G-CSF), and determined how this mechanism differs from that induced by cyclophosphamide with G-CSF or G-CSF alone.
[BMC Cancer]
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Allogeneic Adipose-Derived Stem Cells Promote Ischemic Muscle Repair by Inducing M2 Macrophage Polarization via the HIF -1α/IL -10 Pathway

Scientists found that the ability of RAW264.7 cells to migrate was impaired in hypoxia, whereas coculturing with adipose‐derived mesenchymal stem cells could enhance the migration capacity.
[Stem Cells]
Liu, J., Qiu, P., Qin, J., Wu, X., Wang, X., Yang, X., Li, B., Zhang, W., Ye, K., Peng, Z., & Lu, X. (n.d.). Allogeneic adipose-derived stem cells promote ischemic muscle repair by inducing M2 macrophage polarization via the HIF-1α/IL-10 pathway. STEM CELLS, n/a(n/a). https://doi.org/10.1002/stem.3250 Cite
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Alternative Splicing in Mesenchymal Stem Cell Differentiation

The authors highlight the key alternative splicing (AS) events that modulate MSC differentiation to major osteocytes, chondrocytes, and adipocytes, and discuss the regulatory mechanisms by which AS is regulated.
[Stem Cells]
Park, J. W., Fu, S., Huang, B., & Xu, R.-H. (n.d.). Alternative splicing in mesenchymal stem cell differentiation. STEM CELLS, n/a(n/a). https://doi.org/10.1002/stem.3248 Cite
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