mesenchymal stem cells

[Clinical and Translational Oncology] Researchers investigated the effects of exosomes extracted from human umbilical cord mesenchymal stem cells carrying hsa-miRNA-128-3p on pancreatic cancer cells.

[Hepatology International] Therapy of umbilical cord-derived MSC was not only well tolerated, but also significantly improved long-term survival rate, as well as the liver function in patients with Hepatits B Virus-related decompensated liver cirrhosis.

[AgeX Therapeutics, Inc.] AgeX Therapeutics, Inc. announced that ImStem Biotechnology, Inc., a biopharmaceutical company developing human ESC-derived mesenchymal stem cells, has dosed the first US multiple sclerosis patient with ImStem’s lead investigational drug candidate IMS001.

[Aging] Researchers investigated the effect of maternal age on the biological characteristics and stemness properties of placenta-derived MSCs (PDMSCs). PDMSCs were isolated from 5 donor age groups for comparison of morphological, proliferative and differentiation properties.

[Advanced Science] Coculturing chondrocytes with MSCs derived from gingival lamina propria produced abundant “matrix bound gingival MSC derived extracellular vesicles” in forming cartilaginous extracellular matrix (ECM), which were further preserved in acellular cartilaginous ECM following mild, short-period decellularization.

[Critical Reviews in Oncology/Hematology] The authors review the role of enhancer of zeste homology 2 (EZH2) in regulating bone marrow MSC differentiation and the immune cell function in tumor microenvironment, summarize all types of existing EZH2 inhibitors and the main clinical trials, and propose relevant ideas for potential clinical applications.