mesenchymal stem cells

[AgeX Therapeutics, Inc. (BusinessWire, Inc.)] AgeX Therapeutics, Inc. announced that ImStem Biotechnology, Inc. has dosed the first US multiple sclerosis patient with ImStem’s lead investigational drug candidate IMS001.

[Aging] The authors investigated the effects of bone morphogenetic protein 9 on osteogenesis and angiogenesis of human amniotic mesenchymal stem cells (hAMSCs) cocultured with human umbilical vein endothelial cells (HUVECs) and determined the possible underlying molecular mechanism.

[Stem Cell Research & Therapy] The authors outline current approaches aiming to improve the beneficial outcomes of cell therapy to better grasp clinical cell transformation.

[Journal of Tissue Engineering and Regenerative Medicine] Researchers found that miR-129-5p inhibited high mobility group box 1 (HMGB1) expression in bone marrow MSCs. Myocardial infraction mice treated with exosomes overexpressing miR-129-5p had enhanced cardiac function and decreased expression of HMGB1 and production of inflammatory cytokines.

[Chemosphere] The authors summarize the effects of nanomaterials on the proliferation and differentiation of ESCs, mesenchymal stem cells and neural stem cells.

[British Journal of Haematology] Scientists investigated leukemia-bone marrow (BM) niche-associated signaling and identified signaling cascades supporting the interaction of leukemic cells and BM MSCs. They demonstrated functional differences between MSCs originating from leukemic and healthy donors.