The authors discuss recent findings on the complex nature of MSCs, focusing on their elusive impact on glioblastoma progression and aggressiveness by direct cell‐cell interaction and via secretome, also facing the perspectives and challenges in treatment strategies.
Bajetto, A., Thellung, S., Dellacasagrande, I., Pagano, A., Barbieri, F., & Florio, T. (n.d.). Cross talk between mesenchymal and glioblastoma stem cells: Communication beyond controversies. STEM CELLS Translational Medicine, n/a(n/a). https://doi.org/10.1002/sctm.20-0161Cite
Investigators report that mesenchymal stem cells (MSCs) sheltered Mybacterium tuberculosis (Mtb) to help tolerate anti-TB drugs. MSCs readily took up Mtb and allowed unabated mycobacterial growth despite having a functional innate pathway of phagosome maturation.
Schüttler, K. F., Bauhofer, M. W., Ketter, V., Giese, K., Eschbach, D. A., Yenigün, M., Fuchs-Winkelmann, S., & Paletta, J. R. J. (2020). Direct incorporation of mesenchymal stem cells into a Nanofiber scaffold – in vitro and in vivo analysis. Scientific Reports, 10(1), 9557. https://doi.org/10.1038/s41598-020-66281-6Cite
Crivaro, A., Bondar, C., Mucci, J. M., Ormazabal, M., Feldman, R. A., Delpino, M. V., & Rozenfeld, P. A. (2020). Gaucher disease-associated alterations in mesenchymal stem cells reduce osteogenesis and favour adipogenesis processes with concomitant increased osteoclastogenesis. Molecular Genetics and Metabolism. https://doi.org/10.1016/j.ymgme.2020.06.003Cite