mesenchymal stem cells

[Science Advances] Researchers developed fibrous hydrogel assemblies that were stabilized with photocrosslinking and displayed fiber density–dependent strain-responsive properties.

[Cancer Letters] The authors address the noncanonical roles of p53 and their implications in sarcoma initiation and progression.

[Stem Cell Research & Therapy] The authors showed that donor differences in human MSC (hMSC) transcriptome were minor relative to the intrinsic differences in tissue-of-origin. hMSCs with different transcriptomic profiles showed potential differences in functional characteristics.

[Stem Cell Research & Therapy] Investigators explored the effects of PPARβ/δ agonist on the regeneration of diabetic bone defects and the osteogenic differentiation of rat bone marrow MSCs under a pathological high-glucose condition.

[Advanced Science] Among various cell sources, FGL1/PD-L1 small extracellular vesicles (sEVs) derived from MSCs not only enriched FGL1/PD-L1 expression but also maintained the immunomodulatory properties of unmodified MSC sEVs.

[Scientific Reports] Scientists determined the effect of transplanting rat cranial bone-derived MSCs (rcMSCs) in rat spinal cord injury models. The transplantation of rcMSCs improved motor function and electrophysiology recovery, and reduced cavity ratio.