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mesenchymal stem cells

Exosomes from Bone Marrow Mesenchymal Stem Cells Promoted Osteogenic Differentiation by Delivering miR-196a That Targeted Dickkopf-1 to Activate Wnt/β-Catenin Pathway

[Bioengineered] Researchers demonstrated that exosomes extracted from bone marrow MSCs (BMSC-exo) significantly promoted HFOB1.19 differentiation to osteoblasts, and found that BMSC-exo were enriched with miR-196a and delivered miR-196a to HFOB1.19 cells to inhibit its target Dkk1, which was a negative regulator of Wnt/β-catenin pathway.

Human Umbilical Mesenchymal Stromal Cells Mixed with Hyaluronan Transplantation Decreased Cartilage Destruction in a Rabbit Osteoarthritis Model

[Stem Cells International] The authors evaluated the capability of human umbilical cord mesenchymal stromal cells mixed with hyaluronan to treat osteoarthritis in a rabbit model.

Management of Intrauterine Adhesions Using Human Amniotic Mesenchymal Stromal Cells to Promote Endometrial Regeneration and Repair through Notch Signaling

[Journal of Cellular and Molecular Medicine] Investigators examined the function of Notch signaling in intrauterine adhesions treatment with human amniotic mesenchymal stromal cell (hAMSC) transplantation, and found that it mediated the differentiation of hAMSCs into endometrial epithelial cells, thus promoting endometrial regeneration and repair.

Mesenchymal Stem Cells-Derived Exosomes for Drug Delivery

[Stem Cell Research & Therapy] Scientists review the studies on exosomes secreted by mesenchymal stem cells (MSC-EXOs) for drug delivery, summarize the characteristics of MSC-EXOs, and introduce the primary production and purification methods and drug loading methods to provide solutions for existing problems and suggestions for future studies.

Adipogenic Progenitors in Different Organs: Pathophysiological Implications

[Reviews in Endocrine & Metabolic Disorders] The authors summarize some of the knowledge regarding the presence of adipose tissue in particular tissues, describing the composition of its adipogenic precursors, and the interactions responsible for the development of organ pathologies.

Insights of Extracellular Vesicles of Mesenchymal Stem Cells: A Prospective Cell-Free Regenerative Medicine for Neurodegenerative Disorders

[Molecular Neurobiology] Due to paucity of standard protocols in extraction procedures of extracellular vesicles (EVs) and their pharmacological properties and mechanisms, the development of new EV dependent therapies is challenging.

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