Tag results:
mesenchymal stem cells
Mesenchymal Cell News
Safety, Tolerability, and Activity of Mesenchymal Stem Cells versus Placebo in Multiple Sclerosis (MESEMS): A Phase II, Randomised, Double-Blind Crossover Trial
[Lancet Neurology] Bone marrow-derived MSC treatment was safe and well tolerated but did not show an effect on gadolinium-enhancing lesions, an MRI surrogate marker of acute inflammation, in patients with active forms of multiple sclerosis, at week 24.
Mesenchymal Cell News
Mesenchymal Stem Cell Treatment Improves Outcome of COVID-19 Patients via Multiple Immunomodulatory Mechanisms
[Cell Research] MSC infusion reduced the levels of C-reactive protein, proinflammatory cytokines, and neutrophil extracellular traps, and promoted the maintenance of SARS-CoV-2-specific antibodies.
Mesenchymal Cell News
Roe-Inspired Stem Cell Microcapsules for Inflammatory Bowel Disease Treatment
[Proceedings of the National Academy of Sciences of the United States of America] Inspired by the natural incubation mechanism of roe, investigators presented immune-isolating, wet-adhesive, and nutrient-rich microcapsules for therapeutic MSCs encapsulation.
Mesenchymal Cell News
Metabolomics and Cytokine Profiling of Mesenchymal Stromal Cells Identify Markers Predictive of T-Cell Suppression
[Cytotherapy] The authors provided a platform for identifying markers for predicting MSC functional capacity using partial least squares regression modeling that could be used as release criteria and guide future manufacturing strategies for mesenchymal stromal cells and other cell therapies.
Mesenchymal Cell News
Brain-Derived Neurotrophic Factor Promotes Immune Reconstitution Following Radiation Injury via Activation of Bone Marrow Mesenchymal Stem Cells
[PLoS One] Brain-derived neurotrophic factor promoted hematopoietic regeneration via activation of PDGFRα+ bone marrow MSCs which increased secretion of hematopoietic cytokines interleukin 6 and leukemia inhibitory factor in response to TrkB activation.
Mesenchymal Cell News
Bone Marrow Mesenchymal Stem Cells Offer an Immune-Privileged Niche to Cutibacterium acnes in Case of Implant-Associated Osteomyelitis
[Acta Biomaterialia] Researchers examined MSCs/C. acnes interaction and analyzed the subsequent MSCs and bacteria's behaviors. Infected MSCs increased the secretion of prostaglandin E2 and indolamine 2,3 dioxygenase immunomodulatory mediators.