mesenchymal stem cells

[Stem Cell Reviews and Reports] DPP4 activity may modulate different aspects of MSC regenerative capacity. The authors analyze the effect of different DPP4 substrates on MSC and discuss how the regulation of DPP4 activity by DPP4 inhibitor can be applied in regenerative medicine.

[Stem Cell Research & Therapy] Scientists demonstrated that placenta-derived mesenchymal stem cells improved hepatic functions by regulating endoplasmic reticulum stress and calcium channels in a rat model of bile duct ligation.

[Cellular Reprogramming] MSCs were extracted from adipose, umbilical cord, and placental tissues. The expression levels of 80 cytokines were detected, and the data demonstrated that the three MSC types abundantly secreted insulin-like growth factor-binding protein (IGFBP)-4, IGFBP-3, tissue inhibitor of metalloproteinase (TIMP)-1, TIMP-2, IGFBP-6, monocyte chemoattractant protein-1, and granulocyte colony-stimulating factor.

[Stem Cells and Development] Investigators explored the possible mechanism of hepatocyte growth factor-transfectedhuman umbilical cord mesenchymal stem cells in inhibiting the proliferation and activation of hepatic stellate cells-T6.

[Journal of Cellular Physiology] Investigators assessed the Mucin 1-mediated effect of hypoxia on the proteomic composition of human osteoblast-derived extracellular matrices (ECM) and characterized their osteogenic and angiogenic potentials in the produced ECMs.

[Nature Communications] By exome sequencing of in vitro expanded mesenchymal stromal cells (MSCs) from 98 patients with myelodysplastic syndrome (MDS) and 28 healthy controls, scientists showed that these cells accumulated recurrent mutations in genes such as ZFX, RANK, and others.