mesenchymal stem cells

[Signal Transduction and Targeted Therapy] In vitro results showed that MSC-small extracellular vesicles reduced senescent biomarkers, decreased senescence-associated secretory phenotype, rescued angiogenesis, migration and other dysfunctions in senescent endothelial cell induced by oxidative stress.

[Stem Cell Reviews and Reports] Scientists investigated very small embryonic-like cells (VSELs)-like cells in terms of their pluripotency phenotype and tri-lineage differentiation potential.

[Journal of Cellular and Molecular Medicine] The authors evaluated the tissue distribution and potential toxicity of thrombin-preconditioned human Wharton's jelly-derived MSCs in animal models before the initiation of clinical trials.

[Molecular Therapy] Scientists revealed that MSC-derived exosomes resided specifically in the injured kidney and delivered miRNA-34c-5p to reduce cellular activation and renal interstitial fibrosis by inhibiting core fucosylation.

[NPJ Regenerative Medicine] Investigators show that store-dependent Ca2+ entry was essential for modulating the function of bone marrow-derived MSCs.

[Stem Cell Reviews and Reports] The authors generated NMPs from human ESCs, subsequently derived MSCs and characterized this cell population in vitro and in vivo. NMP-derived MSCs were plastic adherent fibroblast like cells with colony forming capacity and trilineage (osteo-, chondro- and adipo-genic) differentiation potential.