The authors highlight the key alternative splicing (AS) events that modulate MSC differentiation to major osteocytes, chondrocytes, and adipocytes, and discuss the regulatory mechanisms by which AS is regulated.
The authors review the potential use of stem cells in elderly burn wounds, as well as the mechanisms by which mesenchymal stem cell- based therapies may impact burn wound healing in the elderly.
[International Journal of Molecular Sciences]
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Decidual MSCs displayed stem cell-like properties and were of maternal origin. Important cell properties and lipid profiles were assessed and compared between spontaneous onset of labor- and not in labor-decidual MSCs.
[Molecular Human Reproduction]
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Wijaya, J. C., Khanabdali, R., Georgiou, H. M., Kokkinos, M. I., James, P. F., Brennecke, S. P., & Kalionis, B. (n.d.). Functional Changes in Decidual Mesenchymal Stem/Stromal Cells are Associated with Spontaneous Onset of Labour. Molecular Human Reproduction. https://doi.org/10.1093/molehr/gaaa045 Cite
Investigators showed that intracerebroventricularly injected bone marrow mesenchymal stem cells improved cognitive impairment in Alzheimer’s disease model mice by ameliorating astrocytic inflammation as well as synaptogenesis.
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Nakano, M., Kubota, K., Kobayashi, E., Chikenji, T. S., Saito, Y., Konari, N., & Fujimiya, M. (2020). Bone marrow-derived mesenchymal stem cells improve cognitive impairment in an Alzheimer’s disease model by increasing the expression of microRNA-146a in hippocampus. Scientific Reports, 10(1), 10772. https://doi.org/10.1038/s41598-020-67460-1 Cite
Rabbit peripheral blood-derived mononuclear cells were isolated using density gradient centrifugation and was evaluated for mesenchymal cell properties including stemness.
[Journal of Tissue Engineering and Regenerative Medicine]
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Venugopal, B., Mohan, S., Kumary, T. V., & Anil Kumar, P. R. (2020). Peripheral Blood As a Source of Stem Cells for Regenerative Medicine: Emphasis Towards Corneal Epithelial Reconstruction—An In Vitro Study. Tissue Engineering and Regenerative Medicine. https://doi.org/10.1007/s13770-020-00273-5 Cite
Mesenchymal stromal cell-derived exosomes could deliver their carried miR-132-3p into target ECs, which functionally downregulated the target protein RASA1, while upregulated the expression of Ras and the downstream PI3K phosphorylation.
[Stem Cell Research & Therapy]
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Pan, Q., Kuang, X., Cai, S., Wang, X., Du, D., Wang, J., Wang, Y., Chen, Y., Bihl, J., Chen, Y., Zhao, B., & Ma, X. (2020). miR-132-3p priming enhances the effects of mesenchymal stromal cell-derived exosomes on ameliorating brain ischemic injury. Stem Cell Research & Therapy, 11(1), 260. https://doi.org/10.1186/s13287-020-01761-0 Cite
Researchers found that the co‑transplantation of tonsil‑derived mesenchymal stromal cells (T‑MSCs) with bone marrow‑derived cells (BMCs) accelerated the recovery of involuted thymuses in mice following partial pre‑bone marrow transplantation conditioning with busulfan‑cyclophosphamide treatment, possibly by inducing FMS‑like tyrosine kinase 3 ligand and fibroblast growth factor 7 production in T‑MSCs.
[International Journal of Molecular Medicine]
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Choi, D.-W., Cho, K.-A., Lee, H.-J., Kim, Y.-H., Woo, K.-J., Park, J.-W., Ryu, K.-H., & Woo, S.-Y. (2020). Co‑transplantation of tonsil‑derived mesenchymal stromal cells in bone marrow transplantation promotes thymus regeneration and T cell diversity following cytotoxic conditioning. International Journal of Molecular Medicine. https://doi.org/10.3892/ijmm.2020.4657 Cite
Scientists identified that exosomes derived from HO-1/BMMSCs played an important role in alleviating the inflammatory injury of intestinal epithelial cells (IECs). The mechanism was related to miR-200b targeting the abnormally increased expression of the high mobility group box 3 (HMGB) gene in IECs induced by inflammatory injury. The reduced level of HMGB3 then decreases the inflammatory injury.
[Cell Death & Disease]
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Scientists found that across three human MSC donors, MSCs increased their expression of indoleamine-2,3-dioxygenase in response to both increased dose of IFNγ and duration of pre-licensing.
[Journal of the Royal Society interface]
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Boyt, D. T., Boland, L. K., Burand, A. J., Brown, A. J., & Ankrum, J. A. (2020). Dose and duration of interferon γ pre-licensing interact with donor characteristics to influence the expression and function of indoleamine-2,3-dioxygenase in mesenchymal stromal cells. Journal of The Royal Society Interface, 17(167), 20190815. https://doi.org/10.1098/rsif.2019.0815 Cite
Scientists demonstrated that MSC-derived factors could stimulate oligodendrogenesis and myelin sheath generation of adult neural stem cells transplanted into different rodent central nervous system regions.
[International Journal of Molecular Sciences]
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Samper Agrelo, I., Schira-Heinen, J., Beyer, F., Groh, J., Bütermann, C., Estrada, V., Poschmann, G., Bribian, A., Jadasz, J. J., Lopez-Mascaraque, L., Kremer, D., Martini, R., Müller, H. W., Hartung, H. P., Adjaye, J., Stühler, K., & Küry, P. (2020). Secretome Analysis of Mesenchymal Stem Cell Factors Fostering Oligodendroglial Differentiation of Neural Stem Cells In Vivo. International Journal of Molecular Sciences, 21(12), 4350. https://doi.org/10.3390/ijms21124350 Cite
Scientists compared the osteogenic differentiation and bone defect repairment characteristics of bone marrow mesenchymal stem cells sheets derived from alveolar bone and iliac bone in vitro and in vivo.
[Journal of Tissue Engineering]
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