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mesenchymal stem cells

Growth and Mineralization of Osteoblasts from Mesenchymal Stem Cells on Microporous Membranes: Epithelial-Like Growth with Transmembrane Resistance and pH Gradient

[Biochemical and Biophysical Research Communications] MSCs were characterized by flow cytometry with more than 90% CD44 and 75% Sca-1 labeling. Mineralization was validated with paracellular alkaline phosphatase activity, collagen birefringence, and mineral deposition confirming MSCs identity.

Comparing the Renoprotective Effects of BM-MSCs versus BM-MSC-Exosomes, When Combined with an Anti-Fibrotic Drug, in Hypertensive Mice

[Biomedicine & Pharmacotherapy] Scientists determined whether serelaxin (RLX) could enhance the therapeutic efficacy of bone-marrow-derived- mesecnymal stem cell-exosomes (BM-MSC-EXO), and compared the renoprotective effects of RLX and BM-MSC-EXO versus RLX and BM-MSCs in mice with hypertensive CKD.

Tailoring the Proliferation of Fibroblast Cells by Multiresponsive and Thermosensitive Stem Cells Composite F127 Hydrogel Containing Folic acid.MgO:ZnO/Chitosan Hybrid Microparticles for Skin Regeneration

[European Journal of Pharmaceutical Sciences] The authors showed that F127 hydrogel containing FMZC is a suitable and nontoxic construct for encapsulation of MSCs in the presence of lysozyme and UVA irradiation, bearing high stem cell viability and proliferation.

Hop2 Interacts with the Transcription Factor CEBPα and Suppresses Adipocyte Differentiation

[Journal of Biological Chemistry] These in vitro data suggest that Hop2 inhibited adipogenesis by suppressing CEBP-mediated transactivation. Consistent with a negative role for Hop2 in adipogenesis, ablation of Hop2 in mice led to increased body weight, adipose volume, adipocyte size, and adipogenic marker gene expression.

Stem Cell Therapy in Liver Regeneration: Focus on Mesenchymal Stem Cells and Induced Pluripotent Stem Cells

[Pharmacology & Therapeutics] Owing to the recent developments in mesenchymal stem cells and induced pluripotent stem cells, combined with emerging technologies including graphene, nano-biomaterials, and gene editing, precision medicine and individualized clinical treatment may be realized in the near future.

Resveratrol Reverses Osteogenic Decline of Bone Marrow Mesenchymal Stem Cells via Upregulation of YAP Expression in Inflammatory Environment

[Stem Cells and Development] Investigators found that TNF-α could upregulate inflammatory cytokines, Il-6, Mmp-9, and Il-1β, and establish an inflammatory environment.

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