Researchers found that the co‑transplantation of tonsil‑derived mesenchymal stromal cells (T‑MSCs) with bone marrow‑derived cells (BMCs) accelerated the recovery of involuted thymuses in mice following partial pre‑bone marrow transplantation conditioning with busulfan‑cyclophosphamide treatment, possibly by inducing FMS‑like tyrosine kinase 3 ligand and fibroblast growth factor 7 production in T‑MSCs.
Scientists identified that exosomes derived from HO-1/BMMSCs played an important role in alleviating the inflammatory injury of intestinal epithelial cells (IECs). The mechanism was related to miR-200b targeting the abnormally increased expression of the high mobility group box 3 (HMGB) gene in IECs induced by inflammatory injury. The reduced level of HMGB3 then decreases the inflammatory injury.
Scientists demonstrated that MSC-derived factors could stimulate oligodendrogenesis and myelin sheath generation of adult neural stem cells transplanted into different rodent central nervous system regions.
Scientists compared the osteogenic differentiation and bone defect repairment characteristics of bone marrow mesenchymal stem cells sheets derived from alveolar bone and iliac bone in vitro and in vivo.
Investigators demonstrated that the adoptive transfer of gingiva derived mesenchymal stem cells homes to and maintains in the kidney and had a robust therapeutic effect in a spontaneous lupus nephritis model.
Researchers investigated the functional role of a nanosphere loaded with curcumin (CN) in the promotion of the motility of human mesenchymal stem cells (MSCs) during the skin wound healing process. They found that transplantation of umbilical cord blood-MSCs pre-treated with CN enhanced wound closure, granulation, and re-epithelialization at mouse skin wound sites.
Compared with sham or normoxia groups, RT-PCR and western blotting showed that divalent metal transporter 1 expression was significantly increased, and Prussian blue staining, ferrous iro, MDA, and GSH level detection demonstrated that ferroptosis occurred in the infraction myocardium and in cardiomyocyte following hypoxia-induced injury.
The authors discuss recent findings on the complex nature of MSCs, focusing on their elusive impact on glioblastoma progression and aggressiveness by direct cell‐cell interaction and via secretome, also facing the perspectives and challenges in treatment strategies.
Bajetto, A., Thellung, S., Dellacasagrande, I., Pagano, A., Barbieri, F., & Florio, T. (n.d.). Cross talk between mesenchymal and glioblastoma stem cells: Communication beyond controversies. STEM CELLS Translational Medicine, n/a(n/a). https://doi.org/10.1002/sctm.20-0161Cite
Investigators report that mesenchymal stem cells (MSCs) sheltered Mybacterium tuberculosis (Mtb) to help tolerate anti-TB drugs. MSCs readily took up Mtb and allowed unabated mycobacterial growth despite having a functional innate pathway of phagosome maturation.
Schüttler, K. F., Bauhofer, M. W., Ketter, V., Giese, K., Eschbach, D. A., Yenigün, M., Fuchs-Winkelmann, S., & Paletta, J. R. J. (2020). Direct incorporation of mesenchymal stem cells into a Nanofiber scaffold – in vitro and in vivo analysis. Scientific Reports, 10(1), 9557. https://doi.org/10.1038/s41598-020-66281-6Cite
Crivaro, A., Bondar, C., Mucci, J. M., Ormazabal, M., Feldman, R. A., Delpino, M. V., & Rozenfeld, P. A. (2020). Gaucher disease-associated alterations in mesenchymal stem cells reduce osteogenesis and favour adipogenesis processes with concomitant increased osteoclastogenesis. Molecular Genetics and Metabolism. https://doi.org/10.1016/j.ymgme.2020.06.003Cite