mesenchymal stem cells

[Scientific Reports] Scientists investigated the anti-inflammatory effects of MSCs on lipopolysaccharide-stimulated macrophages and the subsequent downregulation of their inflammatory mediators.

[Journal of Biomedical Materials Research Part B-Applied Biomaterials] The authors addressed the contemporary need for a conductive biomimetic nanocomposite scaffold for cardiac tissue engineering by examining the use of a gold nanoparticle-incorporated porcine cholecystic ECM for the same.

[Molecular Pharmaceutics] MiR-155-inhibitor-loaded MSC-derived exosomes showed synergistic effects in keratinocyte migration, restoration of FGF-7 levels, and anti-inflammatory action, leading to accelerated wound healing mediated by negative regulation of miR-155, using an in vitro co-culture model and in vivo mouse model of the diabetic wound.

[Bone Research] Researchers found that the RNA-binding protein Musashi2 regulated bone marrow MSCs (BMSCs) lineage commitment and found that its expression was downregulated during adipogenic differentiation and upregulated during osteogenic differentiation of BMSCs.

[Cell & Bioscience] The authors established a robust method allowing rapid derivation of mesenchymal stem cells from both human iPSCs and ESCs via a temporal induction of neural ectoderm in chemically defined media.

[Experimental Cell Research] Scientists studied the effects of miR-127-3p-enriched extracellular vesicles on choriocarcinoma and underlying mechanisms.