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mesenchymal stem cells

Dysregulated ECM Remodeling Proteins Lead to Aberrant Osteogenesis of Costello Syndrome iPSCs

[Stem Cell Reports] Scientists used Costello syndrome induced pluripotent stem cells (iPSCs) undergoing osteogenic differentiation to investigate how dysregulation of extracellular matrix (ECM) remodeling proteins contributed to impaired osteogenesis.

3D Printing of Cu-Doped Bioactive Glass Composite Scaffolds Promotes Bone Regeneration through Activating the HIF-1α and TNF-α Pathway of hUVECs

[Biomaterials Science] Through in vitro tests, scientists found that copper-doped bioactive glass enhanced angiogenesis by activating the pro-inflammatory environment and the HIF-1α pathway of human umbilical vein endothelial cells.

Schwann Cells Promote Prevascularization and Osteogenesis of Tissue-Engineered Bone via Bone Marrow Mesenchymal Stem Cell-Derived Endothelial Cells

[Stem Cell Research & Therapy] The authors cultured rat Schwann cells, aortic endothelial cells, and bone marrow-derived mesenchymal stem cells (BM-MSCs) and then obtained BM-MSC-derived induced endothelial cells and induced osteoblasts.

The B56α Subunit of PP2A Is Necessary for Mesenchymal Stem Cell Commitment to Adipocyte

[EMBO Reports] The authors reported the PP2A phosphatase B subunit B56α was specifically induced during adipocyte differentiation and mediated PP2A to dephosphorylate GSK3β, thereby blocking Wnt activity and driving adipocyte differentiation.

Effects of Stem Cells from Inducible Brown Adipose Tissue on Diet-Induced Obesity in Mice

[Scientific Reports] Researchers isolated and characterized adipose-derived mesenchymal stem cells from the visceral adipose tissue surrounding a pheochromocytoma, a model of inducible brown adipose tissue in humans.

Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomal microRNA-181a Retards Nasopharyngeal Carcinoma Development by Mediating KDM5C

[Journal of Cancer Research and Clinical Oncology] The mechanism of human umbilical cord MSC-derived exosomal miR-181a was explored in nasopharyngeal carcinoma cell progression.

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