mesenchymal stem cells

[Biomaterials] By modifying a functional polypeptide on the mesenchymal stem cell plasma membrane and exploiting the high expression of transglutaminase 2 in the regions of injured cartilage, researchers achieved targeted recognition and capture of modified MSCs by injured articular chondrocytes

[Scientific Reports] The authors developed a novel 3D magnetic resonance imaging (MRI) analysis software program that provides “projected cartilage area ratios” for automatic detection of changes in cartilage amounts.

[European Journal of Pharmacology] Researchers studied atorvastatin effects on the angiogenesis-signaling pathways from MSCs' differentiation to tissue angiogenesis.

[Molecular Therapy-Nucleic Acids] The authors investigated two promoters, four DNA vectors, two cationic carriers, and four donors of hMSCs from two tissues for efficient hMSC transfection.

[Cynata Therapeutics Limited (BioSpace)] Cynata Therapeutics Limited announced that it has received approval by the Central Adelaide Local Health Network Human Research Ethics Committee to commence a clinical trial of Cynata’s Cymerus™ MSC product in patients with diabetic foot ulcers.

[Molecular Therapy-Nucleic Acids] Investigators explored the relationships among osteoblast differentiation, N-acetyltransferase 10 (NAT10) , and N4-acetylcytidine (ac4C) and found that NAT0 expression and the ac4C level of total RNA were decreased in the bone tissues of OVX mice and osteoporosis patients.