Tag results:
mesenchymal stem cells
Mesenchymal Cell News
Vangl2 Limits Chaperone-Mediated Autophagy to Balance Osteogenic Differentiation in Mesenchymal Stem Cells
[Developmental Cell] Lysosomes are the recycling center and nutrient signaling hub of the cell. The authors showed that lysosomes also control MSC differentiation by proteomic reprogramming.
Mesenchymal Cell News
Establishment of a Systemic Inflammatory Response Syndrome Model and Evaluation of the Efficacy of Umbilical Cord Mesenchymal Stem Cell Transplantation
[Cells Tissues Organs] Based on the characteristics of modern weapon injury, a repetitive model of traumatic systemic inflammatory response syndrome and an evaluation system were established. The models were treated with GFP-labeled tree shrew umbilical cord MSCs.
Mesenchymal Cell News
A Narrative Overview of Utilizing Biomaterials to Recapitulate the Salient Regenerative Features of Dental-Derived Mesenchymal Stem Cells
[International Journal of Oral Science] The authors highlight recent progress and future opportunities in dental MSC-mediated therapeutic strategies for tissue regeneration using two possible approaches, cell transplantation and cell homing.
Mesenchymal Cell News
Updates on Clinical Trials Evaluating the Regenerative Potential of Allogenic Mesenchymal Stem Cells in COVID-19
[npj Regenerative Medicine] Scientists evaluate the safety and efficacy outcomes of the most recent, placebo-controlled Phase I/II clinical studies that enrolled a larger number of patients, in order to provide a statistically relevant and comprehensive understanding of MSC’s therapeutic potential in severe COVID-19 patients.
Cell Therapy News
Advances in Stem Cell Research for the Treatment of Primary Hypogonadism
[Nature Reviews Urology] Over the past two decades, substantial advances have been made in the identification of Leydig cell sources for use in transplantation surgery, including the artificial induction of Leydig-like cells from different types of stem cells, for example, stem Leydig cells, mesenchymal stem cells, and pluripotent stem cells.
Hematopoiesis News
Actin Cytoskeleton Deregulation Confers Midostaurin Resistance in FLT3-Mutant Acute Myeloid Leukemia
[Communications Biology] Midostaurin resistance was overcome by a combination of midostaruin, the BCL-2 inhibitor venetoclax and the RAC1 inhibitor Eht1864 in midostaurin-resistant acute myeloid leukemia (AML) cell lines and primary samples, providing the first evidence of a potential new treatment approach to eradicate FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication + AML.