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mesenchymal stem cells

Vangl2 Limits Chaperone-Mediated Autophagy to Balance Osteogenic Differentiation in Mesenchymal Stem Cells

[Developmental Cell] Lysosomes are the recycling center and nutrient signaling hub of the cell. The authors showed that lysosomes also control MSC differentiation by proteomic reprogramming.

Establishment of a Systemic Inflammatory Response Syndrome Model and Evaluation of the Efficacy of Umbilical Cord Mesenchymal Stem Cell Transplantation

[Cells Tissues Organs] Based on the characteristics of modern weapon injury, a repetitive model of traumatic systemic inflammatory response syndrome and an evaluation system were established. The models were treated with GFP-labeled tree shrew umbilical cord MSCs.

A Narrative Overview of Utilizing Biomaterials to Recapitulate the Salient Regenerative Features of Dental-Derived Mesenchymal Stem Cells

[International Journal of Oral Science] The authors highlight recent progress and future opportunities in dental MSC-mediated therapeutic strategies for tissue regeneration using two possible approaches, cell transplantation and cell homing.

Updates on Clinical Trials Evaluating the Regenerative Potential of Allogenic Mesenchymal Stem Cells in COVID-19

[npj Regenerative Medicine] Scientists evaluate the safety and efficacy outcomes of the most recent, placebo-controlled Phase I/II clinical studies that enrolled a larger number of patients, in order to provide a statistically relevant and comprehensive understanding of MSC’s therapeutic potential in severe COVID-19 patients.

Advances in Stem Cell Research for the Treatment of Primary Hypogonadism

[Nature Reviews Urology] Over the past two decades, substantial advances have been made in the identification of Leydig cell sources for use in transplantation surgery, including the artificial induction of Leydig-like cells from different types of stem cells, for example, stem Leydig cells, mesenchymal stem cells, and pluripotent stem cells.

Actin Cytoskeleton Deregulation Confers Midostaurin Resistance in FLT3-Mutant Acute Myeloid Leukemia

[Communications Biology] Midostaurin resistance was overcome by a combination of midostaruin, the BCL-2 inhibitor venetoclax and the RAC1 inhibitor Eht1864 in midostaurin-resistant acute myeloid leukemia (AML) cell lines and primary samples, providing the first evidence of a potential new treatment approach to eradicate FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication + AML.

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