mesenchymal stem cells

[Scientific Reports] Scientists focused on the communication from MSCs towards osteoclasts-like cells in vitro. MSCs seeded on a calcium-phosphate biomaterial or undergoing induced apoptosis produced a conditioned media favoring the development of osteoclasts from human CD14+ monocytes.

[Stem Cell Research & Therapy] Investigators describe the advances in fat tissue engineering applied to regenerative surgery, through the use of adipose-derived-MSCs, stromal vascular fraction contained in lipofilling/fat graft in wound healing and scar treatment.

[Calidi Biotherapeutics, Inc. (Business Wire, Inc.)] Calidi Biotherapeutics, Inc. announced its partnership with GenScript ProBio for assistance in the advertisement and distribution of Calidi’s proprietary technology platform: SuperNova-1 (SNV-1). The SNV-1 platform is composed of allogeneic, adipose-derived-MSC loaded with an oncolytic agent such as the vaccinia virus.

[Biochemical Pharmacology] Investigators evaluated the in vitro and in vivo antitumor capability of adipose-derived mesenchymal stem cells as a new vehicle for Dearing strain of reovirus loading.

[Scientific Reports] To elucidate cell type-specific differences in the osteogenic differentiation potential and replicative senescence, researchers analyzed the impact of BMP and TGF-β signaling in adipose-derived stromal cells, fibroblasts, and dental pulp stromal cells.

[iScience] RNA-sequencing analysis of zymosan-treated MSCs showed that calcineurin-NFAT inhibition affects extracellular matrix genes, but not cytokine expression that is under the control of the NF-κB pathway.