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microglia

Neuronal Chemokine-Like-Factor 1 (CKLF1) Up-Regulation Promotes M1 Polarization of Microglia in Rat Brain after Stroke

[Acta Pharmacologica Sinica] Researchers showed that CKLF1 was significantly up-regulated in cultured rat cortical neurons subjected to oxygen-glucose deprivation/reoxygenation (ODG/R) injury, but not in cultured rat microglia, astrocytes and oligodendrocytes.

A Neurovascular-Unit-on-a-Chip for the Evaluation of the Restorative Potential of Stem Cell Therapies for Ischaemic Stroke

[Nature Biomedical Engineering] Researchers used the model to track the infiltration of a number of candidate stem cells and to characterize the expression levels of genes associated with post-stroke pathologies.

IFP35 Family Proteins Promote Neuroinflammation and Multiple Sclerosis

[Proceedings of the National Academy of Sciences of the United States of America] In vitro studies demonstrated that IFP35 and NMI were released by multiple cells. IFP35 and NMI subsequently triggered nuclear factor kappa B–dependent activation of microglia via the TLR4 pathway.

The Inhibitory Effects of Orengedokuto on Inducible PGE2 Production in BV-2 Microglial Cells

[Heliyon] Scientists investigated the effects of Orengedokuto on inflammatory molecule induction in BV-2 microglial cells using real-time RT-PCR and ELISA.

Human Sensorimotor Organoids Derived from Healthy and Amyotrophic Lateral Sclerosis Stem Cells Form Neuromuscular Junctions

[Nature Communications] Investigators generated sensorimotor organoids containing physiologically functional neuromuscular junctions and applied the model to different subgroups of amyotrophic lateral sclerosis.

Human Sensorimotor Organoids Derived from Healthy and Amyotrophic Lateral Sclerosis Stem Cells Form Neuromuscular Junctions

[Nature Communications] Investigators generated sensorimotor organoids containing physiologically functional neuromuscular junctions and applied the model to different subgroups of amyotrophic lateral sclerosis.

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