microglia

[Communications Biology] The authors showed that endothelial-induced astrocytes had upregulated expression of A1 astrocytic genes and exhibited a distinctive ECM remodeling profile.

[Neurobiology of Disease] Current evidence points towards infiltrating monocytes as also playing a role in neuron death. Further characterization of the successive molecular changes in both the resident and peripheral immune cells invading the Parkinson's disease brain will provide targets for disease modification.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists identifed a synaptogenic/growth-promoting role for microglia in regulating pyramidal neuron axon initial segment (AIS) synapse formation by chandelier cells, a unique interneuron subtype whose axonal terminals, called cartridges, selectively targeted the AIS.

[Biotechnology and Bioengineering] Scientists investigated whether Schwann cells could be involved in the disease pathogenesis, and developed a tissue-engineered 3D in vitro model that combined motor neurons cocultured with astrocytes.

[Metabolic Brain Disease] The authors review the mechanisms by which a reactive gliosis can induce or contribute to the development and progression of Alzheimer’s disease.

[Cell Reports] Scientists identified C-type lectin Reg3γ as a nociceptor-enriched hormone that protected the host from endotoxic death.