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microglia

The Role of Glial Cells in Multiple Sclerosis Disease Progression

[Nature Reviews Neurology] The authors provide an overview of the involvement of astrocytes and microglia at major sites of pathology in progressive multiple sclerosis.

Wasl Is Crucial to Maintain Microglial Core Activities during Glioblastoma Initiation Stages

[Glia] Scientists identified the underlying mechanism and showed that microglial morphology and functions were already impaired during glioma initiation stages.

Human Umbilical Cord Mesenchymal Stem Cells Derived Exosomes Promote Neurological Function Recovery in a Rat Spinal Cord Injury Model

[Neurochemical Research] Researchers explored the mechanism of hUC-MSC derived exosome's ameliorative effect on the spinal cord injury by combining data from in vivo contusion spinal cord injury model and in vitro cell viability of PC12 cell line stimulated with lipopolysaccharide.

Enhancing Endocannabinoid Signaling in Astrocytes Promotes Recovery from Traumatic Brain Injury

[Brain] Scientists revealed a previously undefined cell type-specific role of 2-arachidonoylglycerol metabolism and signaling pathways in traumatic brain injury-induced neuropathology.

Patchouli Alcohol as a Selective Estrogen Receptor β Agonist Ameliorates AD-Like Pathology of APP/PS1 Model Mice

[Acta Pharmacologica Sinica] The authors identified a natural product patchouli alcohol as a selective estrogen receptor β agonist which improved the cognitive defects in female APP/PS1 mice, and explored the underlying mechanisms.

Extracellular Vesicles from Adipose-Derived Stem Cells Promote Microglia M2 Polarization and Neurological Recovery in a Mouse Model of Transient Middle Cerebral Artery Occlusion

[Current Stem Cell Research & Therapy] The authors explored the contribution of miRNAs in adipose-derived stem cell-extracellular vesicles to the treatment of cerebral ischemia.

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