microglia

[Nature Reviews Cancer] The authors discuss the immune modulatory functions of microglia, monocyte-derived macrophages and astrocytes in brain metastases and glioma.

[Cell Reports] Researchers defined the heterogeneity of microglia and macrophage phenotypes during traumatic brain injury (TBI) in wild-type mice and Ccr2−/− mice, which lacked macrophage influx following TBI and were resistant to brain damage.

[Oncogene] The authors revisit biological characteristics and functions of infiltrating myeloid cells and discuss the recent advances in immunotherapies targeting infiltrating myeloid cells in glioblastoma .

[Cell] Researchers found that microglia exposed to α-syn established a cellular network through the formation of F-actin-dependent intercellular connections, which transfered α-syn from overloaded microglia to neighboring naive microglia where the α-syn cargo got rapidly and effectively degraded.

[Cell Stem Cell] Xenotransplantation of human microglia into cerebral organoids allowed us to characterize key transcriptional programs of developing microglia in vitro and revealed that microglia induced transcriptional changes in neural stem cells and decrease interferon signaling response genes.

[Journal of Nanobiotechnology] Effects of CD73+ human umbilical cord MSC-EVs on hydrolyzing ATP into adenosine were detected. The polarization of M2/M1 was verified by immunofluorescence.