Tag results:
monocytes
Human Immunology News
Distinct Single-Component Adjuvants Steer Human DC-Mediated T-cell Polarization via Toll-Like Receptor Signaling toward a Potent Antiviral Immune Response
[Proceedings of the National Academy of Sciences of the United States of America] Scientists assessed the effect of different adjuvants on human monocyte-derived dendritic cells and their ability to polarize innate and adaptive immune responses.
Mesenchymal Cell News
Functional Mechanism of Bone Marrow-Derived Mesenchymal Stem Cells in the Treatment of Animal Models with Alzheimer’s Disease: Inhibition of Neuroinflammation
[Journal of Inflammation Research] Investigators recapitulate the molecular basis of bone marrow (BM)MSC-assisted biological processes and summarizes the possible mechanisms related to the interaction between BMMSCs and microglia.
Cancer Stem Cell News
Glial and Myeloid Heterogeneity in the Brain Tumor Microenvironment
[Nature Reviews Cancer] The authors discuss the immune modulatory functions of microglia, monocyte-derived macrophages and astrocytes in brain metastases and glioma.
Immune Regulation News
CCR2 Deficiency Alters Activation of Microglia Subsets in Traumatic Brain Injury
[Cell Reports] Researchers defined the heterogeneity of microglia and macrophage phenotypes during traumatic brain injury (TBI) in wild-type mice and Ccr2−/− mice, which lacked macrophage influx following TBI and were resistant to brain damage.
Endothelial Cell News
Growth Arrest Specific-6 and Axl Coordinate Inflammation and Hypertension
[Circulation Research] In human endothelial cells, a striking correlation was observed between the degree of endothelial cell activation as reflected by intracellular adhesion molecule 1, isoLG-adduct accumulation and intracellular GAS6 levels.
Intestinal Cell News
The ATP-Hydrolyzing Ectoenzyme E-NTPD8 Attenuates Colitis through Modulation of P2X4 Receptor–Dependent Metabolism in Myeloid Cells
[Proceedings of the National Academy of Sciences of the United States of America] The molecular mechanism by which microbiota-derived ATP in the colon is regulated remains poorly understood. Researchers showed that E-NTPD8 was highly expressed in large-intestinal epithelial cells and hydrolyzed microbiota-derived luminal ATP.