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monocytes

Distinct Single-Component Adjuvants Steer Human DC-Mediated T-cell Polarization via Toll-Like Receptor Signaling toward a Potent Antiviral Immune Response

[Proceedings of the National Academy of Sciences of the United States of America] Scientists assessed the effect of different adjuvants on human monocyte-derived dendritic cells and their ability to polarize innate and adaptive immune responses.

Functional Mechanism of Bone Marrow-Derived Mesenchymal Stem Cells in the Treatment of Animal Models with Alzheimer’s Disease: Inhibition of Neuroinflammation

[Journal of Inflammation Research] Investigators recapitulate the molecular basis of bone marrow (BM)MSC-assisted biological processes and summarizes the possible mechanisms related to the interaction between BMMSCs and microglia.

Glial and Myeloid Heterogeneity in the Brain Tumor Microenvironment

[Nature Reviews Cancer] The authors discuss the immune modulatory functions of microglia, monocyte-derived macrophages and astrocytes in brain metastases and glioma.

CCR2 Deficiency Alters Activation of Microglia Subsets in Traumatic Brain Injury

[Cell Reports] Researchers defined the heterogeneity of microglia and macrophage phenotypes during traumatic brain injury (TBI) in wild-type mice and Ccr2−/− mice, which lacked macrophage influx following TBI and were resistant to brain damage.

Growth Arrest Specific-6 and Axl Coordinate Inflammation and Hypertension

[Circulation Research] In human endothelial cells, a striking correlation was observed between the degree of endothelial cell activation as reflected by intracellular adhesion molecule 1, isoLG-adduct accumulation and intracellular GAS6 levels.

The ATP-Hydrolyzing Ectoenzyme E-NTPD8 Attenuates Colitis through Modulation of P2X4 Receptor–Dependent Metabolism in Myeloid Cells

[Proceedings of the National Academy of Sciences of the United States of America] The molecular mechanism by which microbiota-derived ATP in the colon is regulated remains poorly understood. Researchers showed that E-NTPD8 was highly expressed in large-intestinal epithelial cells and hydrolyzed microbiota-derived luminal ATP.

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