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multiple sclerosis

Menstrual Blood-Derived Mesenchymal Stromal Cells Efficiently Ameliorate Experimental Autoimmune Encephalomyelitis by Inhibiting T Cell Activation in Mice

[Stem Cell Research & Therapy] Researchers evaluated the therapeutic potential of MSCs isolated from menstrual blood as ready-to-use allo-MSCs in multiple sclerosis by application in its animal model experimental autoimmune encephalomyelitis.

Repeat Infusion of Autologous Bone Marrow Cells in Progressive Multiple Sclerosis – a Phase I Extension Study (SIAMMS II)

[Multiple Sclerosis and Related Disorders] ‘SIAMMS II’ was a prospective, single centre Phase I extension study in which participants in the SIAMMS study were offered repeat bone marrow harvest and infusion of autologous, unfractionated bone marrow as a day-case procedure.

Vaccination and Immunotherapies in Neuroimmunological Diseases

[Nature Reviews Neurology] The authors discuss what is known about the effects of various immunotherapies on immunological responses to vaccines and what these effects mean for the safe and effective use of vaccines in patients with a neuroimmunological disease.

Canadian Prospective Cohort Study to Understand Progression in Multiple Sclerosis Awarded Nearly $1.35 Million to Investigate the Impact of Pediatric-Onset MS Into Adulthood

[Multiple Sclerosis Society of Canada] The Multiple Sclerosis Society of Canada announced today a nearly $1.35 million investment from Biogen Canada Inc., Hoffmann-La Roche Limited, and Brain Canada Foundation towards a new sub-cohort of the Canadian Prospective Cohort Study to Understand Progression in Multiple Sclerosis that follows pediatric-onset MS participants from the Canadian Pediatric Demyelinating Disease Study as they become adults to understand MS across the age-span.

CSF-1 Maintains Pathogenic but Not Homeostatic Myeloid Cells in the Central Nervous System during Autoimmune Neuroinflammation

[Proceedings of the National Academy of Sciences of the United States of America] Investigators found that targeting colony stimulating factor 1 (CSF-1) with neutralizing antibody halted ongoing encephalomyelitis, with efficacy superior to colony CSF-1 receptor inhibitor BLZ945, whereas IL-34 neutralization had no effect, suggesting that pathogenic myeloid cells were maintained by CSF-1.

S1P Analogues SEW2871, BAF312 and FTY720 Affect Human Th17 and Treg Generation Ex Vivo

[International Immunopharmacology] The authors investigated the effects of S1P receptor 1 (S1P1) specific S1P analogue SEW2871, S1P1 and S1P5 specific BAF312, and non-selective FTY720 on human Th17 and Treg differentiation and IL-23-mediated signaling.

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