iPS-Derived Early Oligodendrocyte Progenitor Cells from SPMS Patients Reveal Deficient In Vitro Cell Migration Stimulation

The authors developed iPSCs from secondary progressive multiple sclerosis (SPMS)-affected donors and age-matched controls (CT). They confirmed their efficient and similar oligoprogenitor (OPC) differentiation capacity, although they reported SPMS-OPCs were transcriptionally distinguishable from their CT counterparts.
[Cells]
Lopez-Caraballo, L., Martorell-Marugan, J., Carmona-Sáez, P., & Gonzalez-Munoz, E. (2020). iPS-Derived Early Oligodendrocyte Progenitor Cells from SPMS Patients Reveal Deficient In Vitro Cell Migration Stimulation. Cells, 9(8), 1803. https://doi.org/10.3390/cells9081803 Cite
Full ArticleGraphical Abstract

Continue reading “iPS-Derived Early Oligodendrocyte Progenitor Cells from SPMS Patients Reveal Deficient In Vitro Cell Migration Stimulation”

Bookmark

No account yet? Register

0
Share

Regulatory T Cells Suppress Th17 Cell Ca2+ Signaling in the Spinal Cord during Murine Autoimmune Neuroinflammation

Investigators used two-photon microscopy to elucidate the spatial organization, motility characteristics, and interactions of endogenous Treg and Th17 cells together with antigen-presenting cells within the spinal cord leptomeninges in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis.
[Proceedings of the National Academy of Sciences of the United States of America]
Othy, S., Jairaman, A., Dynes, J. L., Dong, T. X., Tune, C., Yeromin, A. V., Zavala, A., Akunwafo, C., Chen, F., Parker, I., & Cahalan, M. D. (2020). Regulatory T cells suppress Th17 cell Ca2+ signaling in the spinal cord during murine autoimmune neuroinflammation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2006895117 Cite
Full Article

Continue reading “Regulatory T Cells Suppress Th17 Cell Ca2+ Signaling in the Spinal Cord during Murine Autoimmune Neuroinflammation”

Bookmark

No account yet? Register

0
Share
Share