multiple sclerosis

[Cell Death & Differentiation] Researchers investigated the role of Ninj1 in physiological and pathological conditions and developed a strategy to regulate Ninj1 using specific miRNAs under pathological conditions.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers conducted a comprehensive analysis of genome-wide DNA methylation patterns in four peripheral immune cell populations isolated from 29 multiple sclerosis patients at clinical disease onset and 24 healthy controls.

[Current Stem Cell Research & Therapy] Investigators review the potential application of MSC extracellular vesicles as an emerging treatment strategy for optic neuritis by reviewing studies in multiple sclerosis and related disorders.

[Cell] Researchers characterized the heterogeneity, plasticity, and migratory phenotypes of tissue Th17 cells in vivo by combined fate mapping with profiling of the transcriptomes and TCR clonotypes of over 84,000 Th17 cells at homeostasis and during CNS autoimmune inflammation.

[Experimental & Molecular Medicine] Investigators review recent progress in research on the microbial regulation of central nervous system diseases with a focus on major gut microbial metabolites, such as short-chain fatty acids, tryptophan metabolites, and secondary bile acids.

[Neurology-Neuroimmunology & Neuroinflammation] Human CD8+ T lymphocytes from multiple sclerosis donors and age/sex-matched healthy controls were isolated to evaluate the functional impact of soluble ULBP4.