Tag results:
multiple sclerosis
Immune Regulation News
TNF Plays a Crucial Role in Inflammation by Signaling via T Cell TNFR2
[Proceedings of the National Academy of Sciences of the United States of America] Exposure of mouse CD4+ T cells to TNF and TGF-β generated Th17 cells that expressed low levels of IL-17 and high levels of inflammatory markers independently of IL-6 and STAT3.
Immune Regulation News
Antigen-Presenting Innate Lymphoid Cells Orchestrate Neuroinflammation
[Nature] Investigators defined a population of inflammatory group 3 innate lymphoid cells that infiltrate the central nervous system in a mouse model of multiple sclerosis.
ESC & iPSC News
AgeX Therapeutics’ Licensee ImStem Biotechnology Announces First US Multiple Sclerosis Patient Dosed with IMS001
[AgeX Therapeutics, Inc.] AgeX Therapeutics, Inc. announced that ImStem Biotechnology, Inc., a biopharmaceutical company developing human ESC-derived mesenchymal stem cells, has dosed the first US multiple sclerosis patient with ImStem’s lead investigational drug candidate IMS001.
Cell Therapy News
AgeX Therapeutics’ Licensee ImStem Biotechnology Announces First U.S. Multiple Sclerosis Patient Dosed with IMS001
[AgeX Therapeutics, Inc. (BusinessWire, Inc.)] AgeX Therapeutics, Inc. announced that ImStem Biotechnology, Inc. has dosed the first US multiple sclerosis patient with ImStem’s lead investigational drug candidate IMS001.
ESC & iPSC News
Neuronal and Cardiac Toxicity of Pharmacological Compounds Identified through Transcriptomic Analysis of Human Pluripotent Stem Cell-Derived Embryoid Bodies
[Toxicology and Applied Pharmacology] Scientists used human iPSC-derived embryoid bodies as an in vitro model to investigate the embryotoxic effects of a carefully selected set of pharmacological compounds.
Human Immunology News
CD8+ T Cells Specific for Cryptic Apoptosis-Associated Epitopes Exacerbate Experimental Autoimmune Encephalomyelitis
[Cell Death & Disease] The authors found that apoptosis-associated epitopes-specific CD8+ T cells were present in the lymphoid organs of unprimed mice, proliferated under peptide stimulation in vitro, but failed to respond to peptide immunization in vivo, suggesting a physiological control of this response.