The Unified Myofibrillar Matrix for Force Generation in Muscle

Scientists demonstrated that striated muscle cells formed a continuous myofibrillar matrix linked together by frequently branching sarcomeres.
[Nature Communications]
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CFTR Is a Negative Regulator of γδ T Cell IFN-γ Production and Antitumor Immunity

Investigators observed that CFTR was functionally expressed on the cell surface of γδ T cells. Genetic deletion and pharmacological inhibition of CFTR both increased IFN-γ release by peripheral γδ T cells and potentiated the cytolytic activity of these cells against tumor cells both in vitro and in vivo.
[Cellular & Molecular Immunology]
Duan, Y., Li, G., Xu, M., Qi, X., Deng, M., Lin, X., … Yin, Z. (2020). CFTR is a negative regulator of γδ T cell IFN-γ production and antitumor immunity. Cellular & Molecular Immunology, 1–11. https://doi.org/10.1038/s41423-020-0499-3 Cite
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Human Umbilical Cord Blood–Derived MSCs Exosome Attenuate Myocardial Injury by Inhibiting Ferroptosis in Acute Myocardial Infarction Mice

Compared with sham or normoxia groups, RT-PCR and western blotting showed that divalent metal transporter 1 expression was significantly increased, and Prussian blue staining, ferrous iro, MDA, and GSH level detection demonstrated that ferroptosis occurred in the infraction myocardium and in cardiomyocyte following hypoxia-induced injury.
[Cell Biology and Toxicology]
Song, Y., Wang, B., Zhu, X., Hu, J., Sun, J., Xuan, J., & Ge, Z. (2020). Human umbilical cord blood–derived MSCs exosome attenuate myocardial injury by inhibiting ferroptosis in acute myocardial infarction mice. Cell Biology and Toxicology. https://doi.org/10.1007/s10565-020-09530-8 Cite
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Autism-Associated SHANK3 Mutations Impair Maturation of Neuromuscular Junctions and Striated Muscles

Investigators used a combination of patient-derived human iPSCs, Shank3Δ11(−/−) mice, and Phelan-McDermid syndrome muscle biopsies from patients of different ages to analyze the role of SHANK3 on motor unit development.
[Science Translational Medicine]
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miR-195 Enhances Cardiomyogenic Differentiation of the Proepicardium/Septum Transversum by Smurf1 and Foxp1 Modulation

Investigators provide a comprehensive characterization of the developmental expression profile of multiple microRNAs during epicardial development in chicken. They identified that miR-125, miR-146, miR-195 and miR-223 selectively enhanced cardiomyogenesis both in the proepicardium/ST explants as well as in the embryonic epicardium, a Smurf1- and Foxp1-driven process.
[Scientific Reports]
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Cell Type Specific Adhesion to Surfaces Functionalised by Amine Plasma Polymers

The increased resistance observed for the non-endothelial cell types was accompanied by an increased rate of cellular attachment, even though spontaneous migration was comparable to the control, i.e., to the standard cultivation surface. As demonstrated on fibroblasts, the resistance to trypsin was similar in serum-supplemented and serum-free media.
[Scientific Reports]
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Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease

Scientists showed that tri-cellular combinations of human induced pluripotent stem cells (iPSC)-derived cardiomyocytes, cardiac fibroblasts, and cardiac endothelial cells enhanced maturation in easily constructed, scaffold-free, three-dimensional microtissues.
[Cell Stem Cell]
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