Muscle Cell News

[Nature Communications] Scientists demonstrated that striated muscle cells formed a continuous myofibrillar matrix linked together by frequently branching sarcomeres.

[Cellular & Molecular Immunology] Investigators observed that CFTR was functionally expressed on the cell surface of γδ T cells. Genetic deletion and pharmacological inhibition of CFTR both increased IFN-γ release by peripheral γδ T cells and potentiated the cytolytic activity of these cells against tumor cells both in vitro and in vivo.

[Cell Biology and Toxicology] Compared with sham or normoxia groups, RT-PCR and western blotting showed that divalent metal transporter 1 expression was significantly increased, and Prussian blue staining, ferrous iro, MDA, and GSH level detection demonstrated that ferroptosis occurred in the infraction myocardium and in cardiomyocyte following hypoxia-induced injury.

[Science Translational Medicine] Investigators used a combination of patient-derived human iPSCs, Shank3Δ11(−/−) mice, and Phelan-McDermid syndrome muscle biopsies from patients of different ages to analyze the role of SHANK3 on motor unit development.

[Scientific Reports] Investigators provide a comprehensive characterization of the developmental expression profile of multiple microRNAs during epicardial development in chicken. They identified that miR-125, miR-146, miR-195 and miR-223 selectively enhanced cardiomyogenesis both in the proepicardium/ST explants as well as in the embryonic epicardium, a Smurf1- and Foxp1-driven process.

[Scientific Reports] The increased resistance observed for the non-endothelial cell types was accompanied by an increased rate of cellular attachment, even though spontaneous migration was comparable to the control, i.e., to the standard cultivation surface. As demonstrated on fibroblasts, the resistance to trypsin was similar in serum-supplemented and serum-free media.