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muscle cells

High miR203a-3p and miR-375 Expression in the Airways of Smokers with and without COPD

[Scientific Reports] Researchers elucidated the overall smoking-induced miRNA changes and those specific to chronic obstructive pulmonary disease (COPD).They investigated the downstream effects on regulatory gene expression and the correlation to cellular composition.

ACKR3 Regulates Platelet Activation and Ischemia-Reperfusion Tissue Injury

[Nature Communications] Researchers performed ischemia/reperfusion experiments in mice to assess the impact of genetic ACKR3 deficiency in platelets on tissue injury in ischemic myocardium and brain.

Lipid Phosphate Phosphatase 3 in Smooth Muscle Cells Regulates Angiotensin II-Induced Abdominal Aortic Aneurysm Formation

[Scientific Reports] Investigators investigated the role of lipid phosphate phosphatase 3 and lysophospholipid signaling in a well-defined model of pathologic aortic injury.

Cardioprotective Effect of Extracellular Vesicles Derived from Ticagrelor-Pretreated Cardiomyocyte on Hyperglycemic Cardiomyocytes through Alleviation of Oxidative and Endoplasmic Reticulum Stress

[Scientific Reports] Scientists investigated the anti-oxidative and cardioprotective effect of extracellular vesicles derived from ticagrelor-pretreated cardiomyocytes under diabetes mellitus conditions.

Tomatidine-Stimulated Maturation of Human Embryonic Stem Cell-Derived Cardiomyocytes for Modeling Mitochondrial Dysfunction

[Experimental and Molecular Medicine] To enhance the maturation of human embryonic stem cell-derived cardiomyocytes (hESC-CMs), the authors identified a natural steroidal alkaloid, tomatidine, as a new substance that stimulated the maturation of hESC-CMs.

PRMT5 Critically Mediates TMAO-Induced Inflammatory Response in Vascular Smooth Muscle Cells

[Cell Death & Disease] Researchers demonstrated that a positive correlation of protein arginine methyltransferase 5 (PRMT5) expression and trimethylamine N-oxide (TMAO)-induced vascular inflammation, with upregulated vascular cell adhesion molecule-1 expression in primary rat and human vascular smooth muscle cells in vitro.

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