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muscle cells
Cell Therapy News
Long Noncoding RNA LUCAT1 Enhances the Survival and Therapeutic Effects of Mesenchymal Stromal Cells Post-myocardial Infarction
[Molecular Therapy-Nucleic Acids] Using unbiased transcriptome profiling of hypoxia-preconditioned MSCs and normoxic MSCs, scientists identified a lncRNA named lung cancer-associated transcript 1 (LUCAT1) under hypoxia.
Cell Therapy News
CXCR4 Blockade Reduces the Severity of Murine Heart Allograft Rejection by Plasmacytoid Dendritic Cell-Mediated Immune Regulation
[Scientific Reports] Scientists performed fully-mismatched heart transplantations and found combination treatment to result in prolonged allograft survival.
ESC & iPSC News
Robotic High-Throughput Biomanufacturing and Functional Differentiation of Human Pluripotent Stem Cells
[Stem Cell Reports] Investigators established a robotic platform and automated all essential steps of human iPSC culture and differentiation under chemically defined conditions.
ESC & iPSC News
Stage-Specific Regulation of DNA Methylation by TET Enzymes during Human Cardiac Differentiation
[Cell Reports] Researchers characterized stage-specific methylation dynamics and the function of Ten-eleven translocations (TETs) during human cardiomyocyte differentiation. Human ESCs in which all three TET genes were inactivated failed to generate cardiomyocytes, with altered mesoderm patterning and defective cardiac progenitor specification.
Extracellular Matrix News
A Tough Nitric Oxide-Eluting Hydrogel Coating Suppresses Neointimal Hyperplasia on Vascular Stent
[Nature Communications] The authors developed a nitric oxide-eluting hydrogel coating for vascular stents inspired by the biological functions of nitric oxide for cardiovascular system.
Muscle Cell News
AIFM1, Negatively Regulated by miR-145-5p, Aggravates Hypoxia-Induced Cardiomyocyte Injury
[Biomedical Journal] Scientists probed into the role and the underlying regulatory mechanism of apoptosis-inducing factor mitochondria associated 1 (AIFM1) in myocardial injury.