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muscle cells

Long Noncoding RNA LUCAT1 Enhances the Survival and Therapeutic Effects of Mesenchymal Stromal Cells Post-myocardial Infarction

[Molecular Therapy-Nucleic Acids] Using unbiased transcriptome profiling of hypoxia-preconditioned MSCs and normoxic MSCs, scientists identified a lncRNA named lung cancer-associated transcript 1 (LUCAT1) under hypoxia.

CXCR4 Blockade Reduces the Severity of Murine Heart Allograft Rejection by Plasmacytoid Dendritic Cell-Mediated Immune Regulation

[Scientific Reports] Scientists performed fully-mismatched heart transplantations and found combination treatment to result in prolonged allograft survival.

Robotic High-Throughput Biomanufacturing and Functional Differentiation of Human Pluripotent Stem Cells

[Stem Cell Reports] Investigators established a robotic platform and automated all essential steps of human iPSC culture and differentiation under chemically defined conditions.

Stage-Specific Regulation of DNA Methylation by TET Enzymes during Human Cardiac Differentiation

[Cell Reports] Researchers characterized stage-specific methylation dynamics and the function of Ten-eleven translocations (TETs) during human cardiomyocyte differentiation. Human ESCs in which all three TET genes were inactivated failed to generate cardiomyocytes, with altered mesoderm patterning and defective cardiac progenitor specification.

A Tough Nitric Oxide-Eluting Hydrogel Coating Suppresses Neointimal Hyperplasia on Vascular Stent

[Nature Communications] The authors developed a nitric oxide-eluting hydrogel coating for vascular stents inspired by the biological functions of nitric oxide for cardiovascular system.

AIFM1, Negatively Regulated by miR-145-5p, Aggravates Hypoxia-Induced Cardiomyocyte Injury

[Biomedical Journal] Scientists probed into the role and the underlying regulatory mechanism of apoptosis-inducing factor mitochondria associated 1 (AIFM1) in myocardial injury.

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