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muscle cells

The Molecular Mosaic of Regulated Cell Death in the Cardiovascular System

[Biochimica Et Biophysica Acta-Molecular Basis of Disease] Scientists detail each individual process involved in cell death, as well as highlight how they come together to produce various cardiac pathologies.

Distributed Synthesis of Sarcolemmal and Sarcoplasmic Reticulum Membrane Proteins in Cardiac Myocytes

[Basic Research in Cardiology] Researchers identified that the molecular machinery for membrane protein synthesis occurs throughout the cardiac myocyte, and enabled distributed synthesis of membrane proteins within sub-cellular niches where the synthesized protein functions using local mRNA pools trafficked, in part, by microtubules.

miR548ai Antagonism Attenuates Exosome-Induced Endothelial Cell Dysfunction

[Cell Death Discovery] Investigators suggested that miR548ai, a rarely known microRNA, may have provided a molecular target for protection against smooth muscle cell/exosome-induced endothelial cell dysfunction.

Intramuscular Injection of Mesenchymal Stem Cells Activates Anabolic and Catabolic Systems in Mouse Skeletal Muscle

[Scientific Reports] Researchers measured changes in mechanistic target of rapamycin complex 1 signaling, the ubiquitin–proteasome system, and autophagy-lysosome system-related factors after a single intramuscular injection of MSCs with green fluorescence protein into mouse muscles.

Physiologic Biomechanics Enhance Reproducible Contractile Development in a Stem Cell Derived Cardiac Muscle Platform

[Nature Communications] Researchers developed a platform of micron-scale cardiac muscle bundles to control biomechanics in arrays of thousands of purified, independently contracting cardiac muscle strips on two-dimensional elastomer substrates with far greater throughput than single cell methods.

Fortilin Inhibits p53, Halts Cardiomyocyte Apoptosis, and Protects the Heart against Heart Failure

[Cell Death Discovery] Researchers demonstrated that fortilin sustained cardiomyocyte survival at least partly through inhibition of p53 and p53-dependent apoptosis.

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