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muscle cells

Systems for the Functional Evaluation of Human Heart Tissues Derived from Pluripotent Stem Cells

[Stem Cells] Scientists review various modalities to evaluate the function of human stem cell-derived cardiac tissues and introduce heart-on-a-chip systems that can recapitulate physiological parameters of human pluripotent stem cell-derived cardiac tissues.

A Porcine Cholecystic Extracellular Matrix Conductive Scaffold for Cardiac Tissue Repair

[Journal of Biomedical Materials Research Part B-Applied Biomaterials] The authors addressed the contemporary need for a conductive biomimetic nanocomposite scaffold for cardiac tissue engineering by examining the use of a gold nanoparticle-incorporated porcine cholecystic ECM for the same.

Aged Bone Matrix-Derived Extracellular Vesicles as a Messenger for Calcification Paradox

[Nature Communications] The authors showed that extracellular vesicles derived from aged bone matrix during bone resorption favored bone marrow MSC adipogenesis rather than osteogenesis and augmented calcification of vascular smooth muscle cells.

Single-Cell Transcriptomics Reveals Cell-Type-Specific Diversification in Human Heart Failure

[Nature Cardiovascular Research] The authors identified cell-specific transcriptional signatures associated with age and heart failure and reveal the emergence of disease-associated cell states. Notably, cardiomyocytes converged toward common disease-associated cell states, whereas fibroblasts and myeloid cells underwent dramatic diversification.

A Novel Human Stem Cell-Based Biomarker Assay for In Vitro Assessment of Developmental Toxicity

[Birth Defects Research] To identify embryotoxic compounds, scientists developed an hiPSC-based biomarker assay based on the differentiation of hiPSCs into functional cardiomyocytes and hepatocytes.

Recombinant Human Endostatin Combined with Radiotherapy Promotes Cardiomyocyte Apoptosis in Rats via TGFβ1/Smads/CTGF Signaling Pathway

[BMC Cardiovascular Disorders] Scientists investigated the efficacy of recombinant human endostatin combined with radiation on rat cardiomyocyte apoptosis and the regulatory mechanism of transforming growth factor beta1 /Sma and Mad-related protein 3/connective tissue growth factor signaling.

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