myeloid cells

[Immunity] Researchers demonstrated that endothelial cells (ECs) of venules in inflamed tissues exhibited a robust autophagic response that was aligned temporally with the peak of neutrophil trafficking and was strictly localized to EC contacts.

[Journal of Infectious Diseases] Despite the phenotypic and transcriptional similarities between cord blood and adult macrophages, cord blood cells were prone to viral replication when infected with HIV-1.

[Scientific Reports] Scientists showed that interaction with tumor microenvironment elements, mainly activated monocytes through IL-6 secretion, and the extracellular matrix protein fibronectin, induced the Stat3 transcriptional pathway and upregulated ODZ1 which resulted in glioblastoma cell migration.

[International Immunopharmacology] The authors explored the protective effect and preliminary mechanism of Dioscin on dextran sulfate sodium (DSS)-induced colitis in mice and showed that Dioscin reduced DSS-induced disease activity index increase, colon length shortening and colon pathological damage.

[Acta Pharmacologica Sinica] Scientists investigated the effect and underlying mechanism of (R)-4,6-dimethoxy-3-(4-methoxy phenyl)-2,3-dihydro-1H-indanone on acute pancreatitis.

[Nature Communications] Investigators generated sensorimotor organoids containing physiologically functional neuromuscular junctions and applied the model to different subgroups of amyotrophic lateral sclerosis.