Clonal Hematopoiesis and Non-Hematologic Disorders

Researchers review recent studies linking clonal hematopoiesis to altered immune function, inflammation, and non-malignant diseases of aging.
[Blood]
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Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration

The authors leveraged single-cell RNA sequencing in combination with in vivo lineage tracing and organoid models to finely map the trajectories of alveolar-lineage cells during injury repair and lung regeneration.
[Cell Stem Cell]
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Isolation of Murine Bone Marrow by Centrifugation or Flushing for the Analysis of Hematopoietic Cells – A Comparative Study

Researchers adapted a centrifugation-based method for the isolation of murine bone marrow and compared it to the traditional flushing method. Analysis of primary hematopoietic stem cells, immune cells, and megakaryocytes revealed a comparable distribution of cellular (sub)populations.
[Platelets]
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Specific Targeting of Ovarian Tumor-Associated Macrophages by Large, Anionic Nanoparticles

Researchers showed that relatively large anionic nanoparticles administered intraperitoneally selectively accumulated in tumor-associated macrophages.
[Proceedings of the National Academy of Sciences of the United States of America]
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Targeting QKI-7 In Vivo Restores Endothelial Cell Function in Diabete

QKI-7 is highly expressed in human coronary arterial endothelial cells from diabetic donors, and on blood vessels from diabetic critical limb ischemia patients undergoing a lower-limb amputation.
[Nature Communications]
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Alteration of Immunophenotype of Human Macrophages and Monocytes after Exposure to Cigarette Smoke

Using human monocyte-derived macrophages (MDMs) from healthy donors, researchers found that cigarette smoke exposure was not associated with significant changes in the production of pro inflammatory cytokines by MDMs.
[Scientific Reports]
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Histone Deacetylase 3 Controls Lung Alveolar Macrophage Development and Homeostasis

Researchers showed that histone deacetylase 3 was a key epigenetic factor required for avelolar macrophage embryonic development, postnatal homeostasis, maturation, and regeneration from bone marrow.
[Nature Communications]
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Increased CXCL4 Expression in Hematopoietic Cells Links Inflammation and Progression of Bone Marrow Fibrosis in MPN

The authors demonstrated that the absence of hematopoietic CXCL4 ameliorates the myeloproliferative neoplasm phenotype, reduces stromal cell activation and bone marrow fibrosis and decreases the activation of pro-fibrotic pathways in megakaryocytes, inflammation in fibrosis-driving cells and JAK/STAT activation in both megakaryocytes and stromal cells in three murine primary myelofibrosis models.
[Blood]
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Combination Product of Dermal Matrix, Human Mesenchymal Stem Cells, and Timolol Promotes Diabetic Wound Healing in Mice

Scientists investigated whether a bioengineered scaffold device containing hypoxia‐preconditioned, allogeneic human mesenchymal stem cells combined with the beta‐adrenergic antagonist timolol could improve impaired wound healing in diabetic mice.
[Stem Cells Translational Medicine]
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An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages

The authors showed that independently of GSDMD-mediated plasma membrane permeabilization, inflammasome receptors engaged caspase-1 and caspase-8, both of which redundantly promoted activation of apoptotic executioner caspase-3 and caspase-7 in pyroptotic macrophages.
[Cell Reports]
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The Soluble Glycoprotein NMB (GPNMB) Produced by Macrophages Induces Cancer Stemness and Metastasis via CD44 and IL-33

Using mouse tumor models, the authors showed that macrophage-derived soluble glycoprotein nonmetastatic B (GPNMB) increased tumor growth and metastasis in Gpnmb-mutant mice.
[Cellular & Molecular Immunology]
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