myeloid cells

[NPJ Regenerative Medicine] By using studies of gain and loss of function, specific cell depletion approaches, and hematopoietic chimeras researchers demonstrated that tissue regeneration in adult mammals depends on an early and transient peak of granulocyte producing reactive oxygen species and an efficient efferocytosis specifically by tissue-resident macrophages.

[Mucosal Immunology] The authors interrogated the signatures of group 2 innate lymphoid cells from five tissues at the transcriptome and epigenetic level.

[Mucosal Immunology] Using mice specifically defective for either mTORC1 or mTORC2 in ILC3s, scientists show that both mTOR complexes regulate the maintenance of type III Innate lymphoid cells at steady state and pathological immune response during colitis.

[Blood] Interferon-producing Siglec H-positive bone marrow immune cells engaged with O-glycan sialic acid moieties to regulate type I interferon secretion and platelet release, as evidenced by partially normalized platelet count following and inhibition of interferon and Siglec H receptors.

[Cell Research] Scientists constructed a spatiotemporal transcriptome map of mouse fetal liver as a platform for experimental validation of novel regulatory mechanisms underlying HSC and multipotent progenitor expansion.

[Journal of Immunology] Investigators reported that TLR4 was expressed on granulo-monocytic progenitors, as well as mobilized human peripheral blood CD34+ cells. LPS, a component of Gram-negative bacteria that results in a systemic bacterial infection, induced the differentiation of peripheral blood CD34+ cells into myelocytes and monocytes in vitro via the TLR4 signaling pathway.