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myeloid cells

β-Catenin-CCL2 Feedback Loop Mediates Crosstalk between Cancer Cells and Macrophages That Regulates Breast Cancer Stem Cells

[Oncogene] Macrophages co-cultured with breast cancer cells showed a significant increase in CCL2 expression and promoted β-Catenin-induced breast cancer stem cells (BCSCs) properties, whereas depletion of CCL2 by adding neutralizing antibodies suppressed BSCSs properties.

Human Autoinflammatory Disease Reveals ELF4 as a Transcriptional Regulator of Inflammation

[Nature Immunology] Using cells from patients and newly generated mouse models, investigators uncovered ELF4-mutant macrophages having hyperinflammatory responses to a range of innate stimuli.

Cross-Tissue Single-Cell Landscape of Human Monocytes and Macrophages in Health and Disease

[Immunity] Researchers focused on IL4I1+CD274(PD-L1)+IDO1+ macrophages, which accumulated in the tumor periphery in a T cell-dependent manner via interferon-γ (IFN-γ) and CD40/CD40L-induced maturation from IFN-primed monocytes.

Multimodal Single-Cell Omics Analysis Identifies Epithelium–Immune Cell Interactions and Immune Vulnerability Associated with Sex Differences in COVID-19

[Signal Transduction and Targeted Therapy] Investigators inspected sex differences in SARS-CoV-2 infection, hospitalization, admission to the intensive care unit (ICU), sera inflammatory biomarker profiling, and single-cell RNA-sequencing profiles across nasal, bronchoalveolar lavage fluid, and peripheral blood mononuclear cells from COVID-19 patients with varying degrees of disease severities.

SARS-CoV-2 Specific T Cell Responses Are Lower in Children and Increase with Age and Time after Infection

[Nature Communications] Scientists reported SARS-CoV-2 specific T cell responses in infected adults and children and find that the acute and memory CD4+ T cell responses to structural SARS-CoV-2 proteins increase with age, whereas CD8+ T cell responses increase with time post-infection.

Host Defense against Klebsiella pneumoniae Pneumonia Is Augmented by Lung-Derived Mesenchymal Stem Cells

[Journal of Immunology] Scientists determined the immunomodulatory, antibacterial, and therapeutic potential of purified murine stem cell Ag-1+ lung MSCs using in vitro cell culture and an in vivo mouse model of pneumonia caused by K. pneumoniae.

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