myeloid cells

[Circulation Research] Scientists generated transgenic (Tg) rabbits with smooth muscle cell-specific PGC1α overexpression and showed that these rabbits developed significantly less aortic atherosclerosis than their non-Tg littermates after high-cholesterol diet feeding, while total plasma cholesterol levels were similar.

[npj Breast Cancer] Using a novel approach in estrogen receptor-positive (ER+) and negative breast cancer, researchers identified perinuclear-localized expression of STING in ER+ cases as an independent predictor of good prognosis, associated with immune cell infiltration and upregulation of immune checkpoints.

[Scientific Reports] Scientists evaluated lipopolysaccharide (LPS)- and interleukin 4 (IL4)-stimulated microglial uptake of [14C]2DG and [18F]BCPP-EF to give a new insight into the hypothesis that different uptake of [18F]FDG and [18F]BCPP-EF could be ascribed to the different metabolic pathways activated during microglial activation.

[Nature Communications] Scientists integrated genome-wide chromosome conformation data from purified neurons and glia with transcriptomic and enhancer profiles, to characterize the gene regulatory landscape of two major cell classes in the human brain.

[Scientific Reports] Apoptotic cell phagocytosis and soluble TREM2 shedding were unaltered, suggesting a disjoint between the pathways and the signaling cascades downstream of triggering receptor on myeloid cells 2 (TREM2) in R47H-expressing induced pluripotent stem cell-derived microglia (iPS-Mg), whilst metabolic deficits in glycolytic capacity and maximum respiration were reversed when R47H expressing iPS-Mg were exposed to phosphatidylserine+ expressing cells.

[Scientific Reports] Scientists characterized the immune processes induced by the epithelium after urban particulate matter exposure in special regard to interactions with monocyte-derived dendritic cells and monocyte-derived macrophages in obstructive lung diseases.