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myeloid cells

Placental Chorionic Plate-Derived Mesenchymal Stem Cells Ameliorate Severe Acute Pancreatitis by Regulating Macrophage Polarization via Secreting TSG-6

[Stem Cell Research & Therapy] The survival and colonization of exogenous placental chorionic plate-derived MSCs were observed by bioluminescence imaging and CM-Dil labeling in rodent animal models of severe acute pancreatitis.

Single-Cell RNA Sequencing Identify SDCBP in ACE2-Positive Bronchial Epithelial Cells Negatively Correlates with COVID-19 Severity

[Journal of Cellular and Molecular Medicine] Since angiotensin-converting enzyme 2 (ACE2)-positive cells were hosts for COVID-19, researchers focussed on this cell type to explore the underlying mechanisms of COVID-19.

AMPK Activates Parkin Independent Autophagy and Improves Post Sepsis Immune Defense against Secondary Bacterial Lung Infections

[Scientific Reports] Scientists showed acquired Parkin and AMPK deficiency in leukocytes of post-sepsis immunosuppression from human subjects and mice.

Inhibition of the DNA Damage Response Phosphatase PPM1D Reprograms Neutrophils to Enhance Anti-Tumor Immune Responses

[Nature Communications] Scientists showed that mice with genetic knockout of Ppm1d or with conditional knockout of Ppm1d in the hematopoietic system, in myeloid cells, or in neutrophils all displayed significantly reduced growth of syngeneic melanoma or lung carcinoma tumors.

Shoreline Biosciences and BeiGene Announce Strategic Worldwide Collaboration to Develop and Commercialize Genetically Modified Natural Killer (NK) Cell Therapies

[nan] Shoreline Biosciences, Inc. and BeiGene, Ltd. announced a worldwide collaboration to develop and commercialize a portfolio of natural killer (NK)-based cell therapeutics with Shoreline’s iPSC NK cell technology and BeiGene’s research and clinical development capabilities for different malignancies.

Hypothalamic Astrocytes as a Specialized and Responsive Cell Population in Obesity

[International Journal of Molecular Sciences] Scientists provide a comprehensive review of the most relevant findings of molecular and pathophysiological mechanisms by which hypothalamic astrocytes might be involved in the pathogenesis of obesity.

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