myeloid cells

[Brain] Investigators reinforced the connection between aberrant cytosolic-to-endoplasmic reticulum acetyl-CoA flux and the development of an autistic-like phenotype.

[Acta Pharmacologica Sinica] Investigators describe in detail the damage-associated molecular patterns that induce or aggravate neuroinflammation in neurodegenerative diseases including mtDNA, mitochondrial unfolded protein response, mitochondrial reactive oxygen species, adenosine triphosphate, transcription factor A mitochondria, cardiolipin, cytochrome c, mitochondrial Ca2+ and iron.

[Nature Communications] Researchers showed that pyruvate dehydrogenase kinase 1 (PDK1) acted as a targetable determinant of different metabolic states in AML.

[Cell Death & Disease] The authors performed flow cytometry and single-cell RNA sequencing to examine the immune cell landscape of excisional wounds from Angptl4+/+ and Angptl4−/− mice.

[Hepatology] Scientists found that accompanying with dedifferentiation, long-term cultured ProliHH upregulated a panel of chemokines and cytokines related to innate immunity, which were referred as dedifferentiation-associated inflammatory factors.

[Stem Cell Reports] The authors findings supported a direct role for SARS-CoV-2 in mediating endothelial inflammation in an ACE2-dependent or -independent manner.