myeloid cells

[Nature Immunology] Researchers combined a multi-omics approach with longitudinal sampling to reveal temporally resolved protective immune signatures in non-pneumonic and ambulatory SARS-CoV-2 infected patients and associated specific immune trajectories with upper airway viral containment.

[Advanced Healthcare Materials] Investigators developed a delivery platform for small extracellular vesicles derived from gingival MSCs to treat periodontitis.

[Nature Biomedical Engineering] Researchers reported the design, synthesis and performance of a bismuth-based nanoscale metal-organic framework that modulated the immunological and mechanical properties of the tumor microenvironment for enhanced radiotherapy-radiodynamic therapy.

[Blood] Researchers found that megakaryocyte/platelet-specific lactate dehydrogenase A (LdhA)-knockout mice showed an increased number of platelets with remarkably accelerated megakaryocyte maturation and proplatelet formation.

[Hepatology] Scientists analyzed the immune landscapes of hypoxia-low and -high tumor regions using cytometry by time-of-flight, immunohistochemistry and transcriptomic analyses.

[Frontiers in Immunology] Using a human in vitro tri-culture system of macrophages with activated autologous T cells and BRAFV600E mutant melanoma cells, scientists showed that activated T cells and the synthetic triterpenoid the methyl CDDO-Me attenuated immune suppression.