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myeloid cells

CCL2-Mediated Monocytes Regulate Immune Checkpoint Blockade Resistance in Pancreatic Cancer

[International Immunopharmacology] Scientists found that C-C motif chemokine ligand 2 (CCL2) recruits monocytes to and decrease CD8+ T cell infiltration in pancreatic tumors.

Excess Fatty Acids Induce Pancreatic Acinar Cell Pyroptosis through Macrophage M1 Polarization

[BMC Gastroenterology] Scientists found that palmitic acid stimulation led to M1 polarization of macrophage, which secreted cathepsin S via exosomes to pancreatic acinar cells and led to activation of the caspase1-mediated classical pyrolysis pathway.

CCL2-Mediated Monocytes Regulate Immune Checkpoint Blockade Resistance in Pancreatic Cancer

[International Immunopharmacology] Scientists found that C-C motif chemokine ligand 2 (CCL2) recruits monocytes to and decrease CD8+ T cell infiltration in pancreatic tumors.

Excess Fatty Acids Induce Pancreatic Acinar Cell Pyroptosis through Macrophage M1 Polarization

[BMC Gastroenterology] Scientists found that palmitic acid stimulation led to M1 polarization of macrophage, which secreted cathepsin S via exosomes to pancreatic acinar cells and led to activation of the caspase1-mediated classical pyrolysis pathway.

Astragali Radix-Coptis Rhizoma Herb Pair Attenuates Atherosclerosis in ApoE-/- Mice by Regulating the M1/M2 and Th1/Th2 Immune Balance and Activating the STAT6 Signaling Pathway

[Evidence-Based Complementary and Alternative Medicine] Scientists focused on the effects and mechanisms of the Astragali Radix and Coptis Rhizoma herb pair attenuation of atherosclerosis in apolipoprotein E knockout (ApoE-/-) mice.

Lin28B-High Breast Cancer Cells Promote Immune Suppression in the Lung Pre-metastatic Niche via Exosomes and Support Cancer Progression

[Nature Communications] Researchers demonstrated that Lin28B promoted lung metastasis of breast cancer by building an immune-suppressive pre-metastatic niche.

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