myeloid cells

[JCI Insight] Investigators identified that only Trastuzumab+Pertuzumab combination therapy, but not when either antibody used in isolation, allowed for the activation of the classical complement pathway, resulting in both direct complement-dependent cytotoxicity as well as complement-dependent cellular phagocytosis of HER2+ breast cancer cells.

[Science Advances] Investigators developed a system for the production of platelet precursor cells, megakaryocytes, from PSCs. These cultures could be maintained for greater than 100 days, implying culture renewal by megakaryocyte progenitors.

[Gut] Scientists elucidated the nature, regulation and functional relevance of PD-L1+ host cells in HCC.

[Haematologica] Researchers studied the influence of anthropometric and body composition measurements on CAR-T-related immunotoxicity in 64 patients receiving CD19-directed CAR-T for relapsed/refractory B cell malignancies.

[Journal of Leukocyte Biology] Researchers hypothesized that cystic fibrosis airway neutrophils contributed to chronic inflammation, in part, via the packaging of inflammasome-inducing signals in extracellular vesicles.

[Scientific Reports] Utilizing dual-single guide RNAs (sgRNAs) and a homology-directed repair template with the CRISPR/Cas9 gene-editing system is a promising avenue for the treatment of glioblastoma multiforme.