myeloid cells

[Phytotherapy Research] Scientists investigated the underlying mechanism and pharmacological effect of rhamnazin against pulmonary disorders.

[Cell Discovery] To delineate the cellular and molecular changes during the development of thoracic aortic aneurysm and dissection (TAAD), scientists performed single-cell RNA sequencing of thoracic aortic cells from β-aminopropionitrile-induced TAAD mouse models at three time points that spanned from the early to the advanced stages of the disease.

[British Journal of Cancer] KDM6A promoted the transcription of SPARCL1 by demethylating histone H3 lysine trimethylation and consequently led to the inactivation of p65. SPARCL1 affected the metastasis of gastrointestinal stromal tumor cells in a mesenchymal-epithelial transition- and matrix-metalloproteinase-dependent manner.

[Developmental Cell] Researchers observed unexpectedly high levels of hepatocyte heterogeneity in the developing liver and the progressive construction of the zonated metabolic functions from pericentral to periportal hepatocytes, which was orchestrated with the development of sinusoid endothelial, stellate, and Kupffer cells.

[Science Translational Medicine] Investigators examined human atopic dermatitis (AD) skin samples and found that human AD fibroblasts also overexpressed C-C motif chemokine ligand 11 (CCL11) and that perturbation of Ikkb–NF-κB in primary human dermal fibroblasts up-regulated CCL11.

[Cell Death & Disease] Scientists assessed the composition and production mechanisms, as well as the clinical significance and biological properties, of soluble CD74 in melanoma.