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myeloid cells

CECR2 Drives Breast Cancer Metastasis by Promoting NF-κB Signaling and Macrophage-Mediated Immune Suppression

[Science Translational Medicine] Investigators found that distant metastases were more immune inert with increased M2 macrophages compared to their matched primary tumors.

Human Invariant Natural Killer T Cells Promote Tolerance by Preferential Apoptosis Induction of Conventional Dendritic Cells

[Haematologica] Dendritic cells were either generated from monocytes or isolated directly from blood of healthy donors or graft-versus-host disease patients and co-cultured in a mixed lymphocyte reaction with T cells obtained from healthy donors or transplantation bags.

Aspirin Activates Resolution Pathways to Reprogram T Cell and Macrophage Responses in Colitis-Associated Colorectal Cancer

[Science Advances] The authors demonstrated that aspirin increased concentrations of the immune-regulatory aspirin-triggered (AT) specialized proresolving mediators, including AT-lipoxin A4 and AT-resolvin D1, in colonic tissues during inflammation-associated colorectal cancer.

NEAT1 in Bone Marrow Mesenchymal Stem Cell-Derived Extracellular Vesicles Promotes Melanoma by Inducing M2 Macrophage Polarization

[Cancer Gene Therapy] Researchers demonstrated that bone marrow MSC-derived extracellular vesicles carrying NEAT1 could promote the progression of melanoma by inducing M2 polarization of macrophages, and thus may be considered as a potential target for melanoma therapeutics.

Exosomal circSHKBP1 Participates in Tumorigenesis, Metastasis, Stemness, Macrophage Polarization and Infiltration in Non-small Cell Lung Cancer through PKM2 Mediated Glycolysis

[Molecular Therapy Oncolytics] Scientists explored the biological function of circSHKBP1 in NSCLC. CircSHKBP1 was found to be upregulated in NSCLC tissues and cell lines and was enriched in exosomes derived from NSCLC cells.

Cytosolic dsRNA Improves Neonatal Innate Immune Responses to Adjuvants in Use in Pediatric Vaccines

[Journal of Leukocyte Biology] Researchers showed that myeloid cells from cord blood could be activated to express T cell costimulatory markers, and also to produced Th1 promoting cytokines.

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