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myeloid cells

Primary Tumor Associated Macrophages Activate Programs of Invasion and Dormancy in Disseminating Tumor Cells

[Nature Communications] Investigators studied the live lung longitudinally and follow the fate of individual disseminated tumor cells that spontaneously disseminated from orthotopic breast tumors.

Lipoxins Modulate Neutrophil Oxidative Burst, Integrin Expression and Lymphatic Transmigration Differentially in Human Health and Atherosclerosis

[FASEB Journal] Scientists evaluated the effects of the specialized pro-resolving mediators lipids, lipoxin A4 and lipoxin B4, on neutrophils isolated from patients with atherosclerosis compared with healthy controls.

CD97 Is Associated with Mitogenic Pathway Activation, Metabolic Reprogramming, and Immune Microenvironment Changes in Glioblastoma

[Scientific Reports] Using in silico and in vitro techniques, investigators demonstrated heterogeneous expression of CD97, a leukocyte adhesion marker, in human glioblastoma.

Patchouli Alcohol as a Selective Estrogen Receptor β Agonist Ameliorates AD-Like Pathology of APP/PS1 Model Mice

[Acta Pharmacologica Sinica] The authors identified a natural product patchouli alcohol as a selective estrogen receptor β agonist which improved the cognitive defects in female APP/PS1 mice, and explored the underlying mechanisms.

Immunomodulatory Matrix-Bound Nanovesicles Mitigate Acute and Chronic Pristane-Induced Rheumatoid Arthritis

[NPJ Regenerative Medicine] Isolated matrix-bound nanovesicles (MBV) were delivered via intravenous or peri-articular injection to rats with pristane-induced arthritis. The results of MBV administration were compared to intraperitoneal administration of methotrexate, the clinical standard of care.

Mesencephalic Astrocyte-Derived Neurotrophic Factor Reprograms Macrophages to Ameliorate Acetaminophen-Induced Acute Liver Injury via p38 MAPK Pathway

[Cell Death & Disease] To investigate the role of myeloid cell MANF in the pathogenesis of AILI, researchers assayed serum and liver samples from acetaminophen-induced liver injury model mice and patients with drug-induced liver injury.

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